HAMAP rule MF_00272
General rule information
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| Accession | MF_00272 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 35) |
| Name | GcvH |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P0A6T9 (GCSH_ECOLI); O32174 (GCSH_BACSU); [ Recover all ] |
| Triggered by |
HAMAP; MF_00272 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | GCSH |
| case <OC:Bacteria> and not <OC:Bacillales> | |
| Protein name | RecName: Full=Glycine cleavage system H protein; |
| end case | |
| case <OC:Bacillales> | |
| Protein name | RecName: Full=Glycine cleavage system H protein; AltName: Full=Octanoyl/lipoyl carrier protein; |
| end case | |
| case <OC:Archaea> | |
| Protein name | RecName: Full=Probable glycine cleavage system H protein; |
| end case | |
| Gene name | Name=gcvH; |
Comments
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| FUNCTION | The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. |
| case <OC:Bacillales> | |
| FUNCTION | Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate. |
| end case | |
| COFACTOR | Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088; Note=Binds 1 lipoyl cofactor covalently.; |
| SUBUNIT | The glycine cleavage system is composed of four proteins: P, T, L and H. |
| SIMILARITY | Belongs to the GcvH family. |
Keywords
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Gene Ontology
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| GO:0019464; Biological process:glycine decarboxylation via glycine cleavage system | |
| case <OCellular component:Bacillales> | |
| GO:0009249; Biological process:protein lipoylation | |
| end case | |
Cross-references
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| Pfam | PF01597; GCV_H; 1; |
| NCBIfam | TIGR00527; GcvH; 1; |
| PROSITE | PS00189; LIPOYL; 1; |
| PROSITE | PS50968; BIOTINYL_LIPOYL; 1; |
Features
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| From: GCSH_ECOLI (P0A6T9) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOD_RES | 65 | 65 | /note="N6-lipoyllysine" | K | ||||||||
Additional information
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| Size range | 115-171 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | The role of GcvH as an octanoyl/lipoyl carrier protein intermediate during protein lipoylation has been shown in Bacillus subtilis (PubMed=21338421, AC:O32174). There are five potential gcvH in AQUAE. |