Annotation rule MF_00272
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General rule information [?]

Accession MF_00272
Dates 1-JUN-2001 (Created)
28-JAN-2015 (Last updated, Version 30)
Name GcvH
Scope Bacteria
Archaea
Templates P0A6T9 (GCSH_ECOLI); O32174 (GCSH_BACSU): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GCSH
case <OC:Bacteria> and not <OC:Bacillales>
Protein name
RecName: Full=Glycine cleavage system H protein;
end case
case <OC:Bacillales>
Protein name
RecName: Full=Glycine cleavage system H protein;
AltName: Full=Octanoyl/lipoyl carrier protein;
end case
case <OC:Archaea>
Protein name
RecName: Full=Probable glycine cleavage system H protein;
end case
Gene name
gcvH

Comments [?]

Function The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
case <OC:Bacillales>
Function Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate.
end case
Cofactor (R)-lipoate
Note: Binds 1 lipoyl cofactor covalently.
Subunit The glycine cleavage system is composed of four proteins: P, T, L and H.
Similarity Belongs to the GcvH family.
Contains 1 lipoyl-binding domain.

Keywords [?]


Gene Ontology [?]

GO:0019464; Biological process: glycine decarboxylation via glycine cleavage system.
case <OC:Bacillales>
GO:0009249; Biological process: protein lipoylation.
end case

Cross-references [?]

Pfam PF01597; GCV_H; 1;
TIGRFAMs TIGR00527; GcvH; 1;
PROSITE PS00189; LIPOYL; 1;
PS50968; BIOTINYL_LIPOYL; 1; trigger=PRU01066;

Features [?]

From: GCSH_ECOLI (P0A6T9)
Key     From     To       Description   Tag   Condition   FTGroup
MOD_RES     65     65       N6-lipoyllysine     K  

Additional information [?]

Size range 115-171 amino acids
Related rules None
Fusion None
Comments The role of GcvH as an octanoyl/lipoyl carrier protein intermediate during protein lipoylation has been shown in Bacillus subtilis (PubMed=21338421, AC:O32174). There are five potential gcvH in AQUAE.