HAMAP rule MF_00285
General rule information
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| Accession | MF_00285 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 65) |
| Name | KdpB |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P03960 (KDPB_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00285 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | KDPB |
| Protein name | RecName: Full=Potassium-transporting ATPase ATP-binding subunit; EC=7.2.2.6; AltName: Full=ATP phosphohydrolase [potassium-transporting] B chain; AltName: Full=Potassium-binding and translocating subunit B; AltName: Full=Potassium-translocating ATPase B chain; |
| Gene name | Name=kdpB; |
Comments
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| FUNCTION | Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm. |
| CATALYTIC ACTIVITY | Reaction=ATP + H2O + K(+)(out) = ADP + H(+) + K(+)(in) + phosphate; Xref=Rhea:RHEA:16777, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29103, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.2.2.6; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16778; |
| SUBUNIT | The system is composed of three essential subunits: KdpA, KdpB and KdpC. |
| case defined <Property:Membrane> and <Property:Membrane=2> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
| else | |
| SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
| end case | |
| SIMILARITY | Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. |
Keywords
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| case defined <Property:Membrane> and <Property:Membrane=2> | |
| Cell inner membrane | |
| end case | |
| Cell membrane | |
| <a href="https://www.uniprot.org/keywords/KW-1278">Translocase</a> | |
| Transport | |
| Ion transport | |
| Potassium | |
| Potassium transport | |
| Membrane | |
| Transmembrane | |
| Phosphoprotein | |
| Magnesium | |
| Metal-binding | |
| ATP-binding | |
| Nucleotide-binding | |
| Transmembrane helix | |
Gene Ontology
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| GO:0005524; Molecular function:ATP binding |
| GO:0000287; Molecular function:magnesium ion binding |
| GO:0008556; Molecular function:P-type potassium transmembrane transporter activity |
| GO:0006813; Biological process:potassium ion transport |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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| Pfam | PF00122; E1-E2_ATPase; 1; |
| Pfam | PF00702; Hydrolase; 1; |
| PRINTS | PR00119; CATATPASE; 1; |
| PRINTS | PR00120; HATPASE; 1; |
| NCBIfam | TIGR01494; ATPase_P-type; 1; |
| NCBIfam | TIGR01497; KdpB; 1; |
| PROSITE | PS00154; ATPASE_E1_E2; 1; |
| General | Transmembrane; -; 7; |
Features
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| From: KDPB_ECOLI (P03960) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 377 | 384 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
F-x-[AS]-x-[TS]-[RK]-x-S | ||||||||
| ACT_SITE | 307 | 307 | /note="4-aspartylphosphate intermediate" | D | ||||||||
| BINDING | 518 | 518 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | ||||||||
| BINDING | 522 | 522 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | ||||||||
| BINDING | 344 | 344 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
D | ||||||||
| BINDING | 348 | 348 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
E | ||||||||
| BINDING | 395 | 395 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
K | ||||||||
Additional information
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| Size range | 620-760 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | The S.typhi ortholog has a 112 amino acid internal deletion and is not used in the alignments. |