HAMAP annotation rule MF_00290
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Accession MF_00290
Dates 1-JUN-2001 (Created)
7-NOV-2011 (Last updated, Version 18)
Name tRNA_dimethyltr_TRM1
Scope Bacteria
Archaea
Triggered by



Identifier
TRM1
case <OC:Archaea>
Protein name
RecName: Full=tRNA (guanine(26)-N(2))-dimethyltransferase;
EC=2.1.1.216;
AltName: Full=tRNA 2,2-dimethylguanosine-26 methyltransferase;
AltName: Full=tRNA(guanine-26,N(2)-N(2)) methyltransferase;
AltName: Full=tRNA(m(2,2)G26)dimethyltransferase;
end case
case <OC:Bacteria>
Protein name
RecName: Full=tRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase;
EC=2.1.1.215;
end case
Gene name
trm1


case <OC:Archaea>
FUNCTION Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups (By similarity).
CATALYTIC ACTIVITY 2 S-adenosyl-L-methionine + guanine(26) in tRNA = 2 S-adenosyl-L-homocysteine + N(2)-dimethylguanine(26) in tRNA.
end case
case <OC:Bacteria>
FUNCTION Dimethylates the guanine residues at position 26 and 27 of one or more tRNAs using S-adenosyl-L-methionine as donor of the methyl groups (By similarity).
CATALYTIC ACTIVITY 4 S-adenosyl-L-methionine + guanine(26)/guanine(27) in tRNA = 4 S-adenosyl-L-homocysteine + N(2)-dimethylguanine(26)/N(2)-dimethylguanine(27) in tRNA.
end case
SIMILARITY Belongs to the TRM1 family.


Transferase
Methyltransferase
tRNA processing
S-adenosyl-L-methionine


GO:0004809; Molecular function: tRNA (guanine-N2-)-methyltransferase activity.
GO:0006400; Biological process: tRNA modification.


Pfam PF02005; TRM; 1;
TIGRFAMs TIGR00308; TRM1; 1;


Size range: 342-401 amino acids
Related Rules: None
Templates: P81554 (TRM1_PYRFU); O67010 (TRM1_AQUAE): [Recover all]
Fusion: None


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