HAMAP rule MF_00290
General rule information
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Accession | MF_00290 |
Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 23) |
Name | tRNA_dimethyltr_TRM1 |
Scope(s) |
Bacteria Archaea |
Template(s) | P81554 (TRM1_PYRFU); O67010 (TRM1_AQUAE); [ Recover all ] |
Triggered by |
HAMAP; MF_00290 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | TRM1 |
case <OC:Archaea> | |
Protein name | RecName: Full=tRNA (guanine(26)-N(2))-dimethyltransferase; EC=2.1.1.216; AltName: Full=tRNA 2,2-dimethylguanosine-26 methyltransferase; AltName: Full=tRNA(guanine-26,N(2)-N(2)) methyltransferase; AltName: Full=tRNA(m(2,2)G26)dimethyltransferase; |
end case | |
case <OC:Bacteria> | |
Protein name | RecName: Full=tRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase; EC=2.1.1.215; |
end case | |
Gene name | Name=trm1; |
Comments
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case <OC:Archaea> | |
FUNCTION | Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. |
CATALYTIC ACTIVITY | Reaction=guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:43140, Rhea:RHEA-COMP:10359, Rhea:RHEA-COMP:10360, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74269, ChEBI:CHEBI:74513; EC=2.1.1.216; |
end case | |
case <OC:Bacteria> | |
FUNCTION | Dimethylates the guanine residues at position 26 and 27 of one or more tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. |
CATALYTIC ACTIVITY | Reaction=guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L- methionine = 4 H(+) + N(2)-dimethylguanosine(26)/N(2)- dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:43136, Rhea:RHEA-COMP:10353, Rhea:RHEA-COMP:10354, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74269, ChEBI:CHEBI:74513; EC=2.1.1.215; |
end case | |
SIMILARITY | Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. |
Keywords
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Gene Ontology
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GO:0004809; Molecular function:tRNA (guanine-N2-)-methyltransferase activity |
GO:0030488; Biological process:tRNA methylation |
Cross-references
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Features
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Additional information
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Size range | 340-420 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |