HAMAP

Accession	MF_00290
Dates	1-JUN-2001 (Created) 7-NOV-2011 (Last updated, Version 18)

Data class

Protein

Predictors

HAMAP; MF_00290; [distribution of match scores in UniProtKB];[seed alignment for MF_00290]

Names

tRNA_dimethyltr_TRM1

Identifier

TRM1

Protein name

RecName: Full=tRNA (guanine(26)-N(2))-dimethyltransferase; EC=2.1.1.216; AltName: Full=tRNA 2,2-dimethylguanosine-26 methyltransferase; AltName: Full=tRNA(guanine-26,N(2)-N(2)) methyltransferase; AltName: Full=tRNA(m(2,2)G26)dimethyltransferase;

Protein name

RecName: Full=tRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase; EC=2.1.1.215;

Gene name

trm1

FUNCTION: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups (By similarity).

CATALYTIC ACTIVITY: 2 S-adenosyl-L-methionine + guanine(26) in tRNA = 2 S-adenosyl-L-homocysteine + N(2)-dimethylguanine(26) in tRNA.

FUNCTION: Dimethylates the guanine residues at position 26 and 27 of one or more tRNAs using S-adenosyl-L-methionine as donor of the methyl groups (By similarity).

CATALYTIC ACTIVITY: 4 S-adenosyl-L-methionine + guanine(26)/guanine(27) in tRNA = 4 S-adenosyl-L-homocysteine + N(2)-dimethylguanine(26)/N(2)-dimethylguanine(27) in tRNA.

SIMILARITY: Belongs to the TRM1 family.

Pfam	PF02005; TRM; 1;
TIGRFAMs	TIGR00308; TRM1; 1;

Transferase, Methyltransferase, tRNA processing, S-adenosyl-L-methionine.

GO:0004809; Molecular function: tRNA (guanine-N2-)-methyltransferase activity.
GO:0006400; Biological process: tRNA modification.

Size range:	342-401 amino acids
Related UniRules:	None
Template:	P81554 (TRM1_PYRFU); O67010 (TRM1_AQUAE): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None