HAMAP rule MF_00298
General rule information
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| Accession | MF_00298 |
| Dates | 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 25) |
| Name | Nudix_RppH |
| Scope(s) |
Bacteria |
| Template(s) | P0A776 (RPPH_ECOLI); Q9ZDT9 (RPPH_RICPR); [ Recover all ] |
| Triggered by |
HAMAP; MF_00298 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | RPPH |
| Protein name | RecName: Full=RNA pyrophosphohydrolase; EC=3.6.1.-; AltName: Full=(Di)nucleoside polyphosphate hydrolase; |
| Gene name | Name=rppH; Synonyms=nudH; |
Comments
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| FUNCTION | Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage. |
| COFACTOR | Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; |
| SIMILARITY | Belongs to the Nudix hydrolase family. RppH subfamily. |
Keywords
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Gene Ontology
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| GO:0016818; Molecular function:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
Cross-references
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| Pfam | PF00293; NUDIX; 1; |
| PRINTS | PR00502; NUDIXFAMILY; 1; |
| PROSITE | PS51462; NUDIX; 1; |
| PROSITE | PS00893; NUDIX_BOX; 1; |
Features
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| From: RPPH_ECOLI (P0A776) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOTIF | 38 | 59 | /note="Nudix box" | |||||||||
Additional information
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| Size range | 155-238 amino acids |
| Related rules |
None |
| Fusion | Nter: <Unknown> Cter: None |
| Comments | Unknown N-terminal domain in COXBU |