HAMAP

Accession	MF_00303
Dates	1-JUN-2001 (Created) 21-NOV-2011 (Last updated, Version 23)

Data class

Protein

Predictors

HAMAP; MF_00303; [distribution of match scores in UniProtKB];[seed alignment for MF_00303]

Names

Trigger_factor_Tig

Identifier

TIG

Protein name

RecName: Full=Trigger factor; Short=TF; EC=5.2.1.8; AltName: Full=PPIase;

Gene name

tig

FUNCTION: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase (By similarity).

CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline (omega=0).

SUBUNIT: Homodimer and monomer. In vivo most of the ribosomes are in complex with monomeric TF. Uncomplexed TF, however, is in a monomer-dimer equilibrium with approximately two thirds of TF existing in a dimeric state (By similarity).

SUBCELLULAR LOCATION: Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm (By similarity).

DOMAIN: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own (By similarity).

SIMILARITY: Belongs to the FKBP-type PPIase family. Tig subfamily.

Pfam	PF00254; FKBP_C; 1; PF05698; Trigger_C; 1; PF05697; Trigger_N; 1;
PIRSF	PIRSF003095; Trigger_factor; 1;
TIGRFAMs	TIGR00115; Tig; 1;
PROSITE	PS50059; FKBP_PPIASE; 1; trigger=PRU00277;

Cell cycle, Cell division, Chaperone, Cytoplasm, Isomerase, Rotamase.

GO:0003755; Molecular function: peptidyl-prolyl cis-trans isomerase activity.
GO:0006457; Biological process: protein folding.
GO:0015031; Biological process: protein transport.

Size range:	404-557 amino acids
Related UniRules:	None
Template:	P0A850 (TIG_ECOLI)
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	Possible wrong start in AQUAE