HAMAP rule MF_00313
General rule information
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| Accession | MF_00313 |
| Dates | 1-JUN-2001 (Created)
2-SEP-2024 (Last updated, Version 25) |
| Name | Glutaminase |
| Scope(s) |
Bacteria |
| Template(s) | O87405 (GLSA_RHIEC); O31465 (GLSA1_BACSU); [ Recover all ] |
| Triggered by |
HAMAP; MF_00313 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | GLSA |
| Protein name | RecName: Full=Glutaminase; EC=3.5.1.2; |
| Gene name | Name=glsA; |
Comments
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| CATALYTIC ACTIVITY | Reaction=L-glutamine + H2O = L-glutamate + NH4(+); Xref=Rhea:RHEA:15889, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:29985, ChEBI:CHEBI:58359; EC=3.5.1.2; |
| SUBUNIT | Homotetramer. |
| SIMILARITY | Belongs to the glutaminase family. |
Keywords
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| case <FT:1> | |
| Acetylation | |
| end case | |
| Hydrolase | |
Gene Ontology
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| GO:0004359; Molecular function:glutaminase activity |
Cross-references
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Features
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| From: GLSA1_BACSU (O31465) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 74 | 74 | /ligand="substrate" | S | ||||||||
| BINDING | 126 | 126 | /ligand="substrate" | N | ||||||||
| BINDING | 170 | 170 | /ligand="substrate" | E | ||||||||
| BINDING | 177 | 177 | /ligand="substrate" | N | ||||||||
| BINDING | 201 | 201 | /ligand="substrate" | Y | ||||||||
| BINDING | 253 | 253 | /ligand="substrate" | Y | ||||||||
| BINDING | 271 | 271 | /ligand="substrate" | V | ||||||||
| From: GLSA1_ECOLI (P77454) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Escherichia> or <OC:Shigella> | ||||||||||||
| MOD_RES | 294 | 294 | /note="N6-acetyllysine" | K | ||||||||
| end case | ||||||||||||
Additional information
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| Size range | 302-340 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: <STAS domain>; <cyclic nucleotide-binding domain> |
| Comments | Possible wrong start in SYNY3 and YERPE |