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HAMAP rule MF_00315

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General rule information [?]

Accession MF_00315
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 36)
Name DXP_synth
Scope(s) Bacteria
Template(s) P77488 (DXS_ECOLI); Q9RUB5 (DXS_DEIRA); [ Recover all ]
Triggered by HAMAP; MF_00315 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier DXS
Protein name RecName: Full=1-deoxy-D-xylulose-5-phosphate synthase;
                 EC=2.2.1.7;
AltName: Full=1-deoxyxylulose-5-phosphate synthase;
                 Short=DXP synthase;
                 Short=DXPS;
Gene name Name=dxs;

Comments [?]

FUNCTIONCatalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP).
CATALYTIC ACTIVITY Reaction=D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D- xylulose 5-phosphate + CO2; Xref=Rhea:RHEA:12605, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57792, ChEBI:CHEBI:59776; EC=2.2.1.7;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.;
COFACTOR Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Note=Binds 1 thiamine pyrophosphate per subunit.;
PATHWAYMetabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5- phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D- glyceraldehyde 3-phosphate and pyruvate: step 1/1.
SUBUNITHomodimer.
SIMILARITYBelongs to the transketolase family. DXPS subfamily.

Keywords [?]


Gene Ontology [?]

GO:0000287; Molecular function:magnesium ion binding
GO:0008661; Molecular function:1-deoxy-D-xylulose-5-phosphate synthase activity
GO:0030976; Molecular function:thiamine pyrophosphate binding
GO:0016114; Biological process:terpenoid biosynthetic process
GO:0009228; Biological process:thiamine biosynthetic process

Cross-references [?]

NCBIfam TIGR00204; Dxs; 1;
PROSITE PS00801; TRANSKETOLASE_1; 1;
PROSITE PS00802; TRANSKETOLASE_2; 1;

Features [?]

From: DXS_ECOLI (P77488)
Key From To Description Tag Condition FTGroup
BINDING 121 123 /ligand="thiamine diphosphate"
/ligand_id="ChEBI:CHEBI:58937"
[GAS]-x-[SAT]
BINDING 153 154 /ligand="thiamine diphosphate"
/ligand_id="ChEBI:CHEBI:58937"
[GA]-[ASTG]
BINDING 152 152 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
D
BINDING 181 181 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
N
BINDING 80 80 /ligand="thiamine diphosphate"
/ligand_id="ChEBI:CHEBI:58937"
H
BINDING 181 181 /ligand="thiamine diphosphate"
/ligand_id="ChEBI:CHEBI:58937"
N
BINDING 288 288 /ligand="thiamine diphosphate"
/ligand_id="ChEBI:CHEBI:58937"
[YFH]
BINDING 370 370 /ligand="thiamine diphosphate"
/ligand_id="ChEBI:CHEBI:58937"
E

Additional information [?]

Size range 583-680 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Atypical sequences in BUCAP and LISMO with internal deletions not taken into account in size range and alignment



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