HAMAP

Accession	MF_00322
Dates	1-JUN-2001 (Created) 9-JUN-2011 (Last updated, Version 21)

Data class

Protein

Predictors

HAMAP; MF_00322; [distribution of match scores in UniProtKB];[seed alignment for MF_00322]

Names

Top6B

Identifier

TOP6B

Protein name

RecName: Full=Type 2 DNA topoisomerase 6 subunit B; EC=5.99.1.3; AltName: Full=Type II DNA topoisomerase VI subunit B; Short=TopoVI-B;

Gene name

top6B

FUNCTION: Relaxes both positive and negative superturns and exhibits a strong decatenase activity. The B subunit binds ATP (By similarity).

CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining of double-stranded DNA.

SUBUNIT: Heterotetramer of two subunits A and two subunits B (By similarity).

SIMILARITY: Belongs to the TOP6B family.

TIGRFAMs

TIGR01052; Top6b; 1;

Isomerase, Topoisomerase, DNA-binding, ATP-binding, Nucleotide-binding.

GO:0005524; Molecular function: ATP binding.
GO:0003677; Molecular function: DNA binding.
GO:0003918; Molecular function: DNA topoisomerase (ATP-hydrolyzing) activity.
GO:0006265; Biological process: DNA topological change.
GO:0006268; Biological process: DNA unwinding involved in replication.

Size range:	523-804 amino acids
Related UniRules:	None
Template:	O05207 (TOP6B_SULSH)
Scope:	Archaea Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None