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HAMAP rule MF_00323
General rule information
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| Accession | MF_00323 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 48) |
| Name | Ferrochelatase |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P32396 (CPFC_BACSU); P23871 (HEMH_ECOLI); Q8Y565 (CPFC_LISMO); [ Recover all ] |
| Triggered by |
HAMAP; MF_00323 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| case <OC:Bacillota> or <OC:Actinomycetota> | |
| Identifier | CPFC |
| Protein name | RecName: Full=Coproporphyrin III ferrochelatase; EC=4.99.1.9; |
| Gene name | Name=cpfC; |
| else | |
| Identifier | HEMH |
| Protein name | RecName: Full=Ferrochelatase; EC=4.98.1.1; AltName: Full=Heme synthase; AltName: Full=Protoheme ferro-lyase; |
| Gene name | Name=hemH; |
| end case | |
Comments
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| case <OC:Bacillota> or <OC:Actinomycetota> | |
| FUNCTION | Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III. |
| CATALYTIC ACTIVITY | Reaction=Fe-coproporphyrin III + 2 H(+) = coproporphyrin III + Fe(2+); Xref=Rhea:RHEA:49572, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033, ChEBI:CHEBI:68438, ChEBI:CHEBI:131725; EC=4.99.1.9; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:49574; |
| PATHWAY | Porphyrin-containing compound metabolism; protoheme biosynthesis. |
| else | |
| FUNCTION | Catalyzes the ferrous insertion into protoporphyrin IX. |
| CATALYTIC ACTIVITY | Reaction=2 H(+) + heme b = Fe(2+) + protoporphyrin IX; Xref=Rhea:RHEA:22584, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033, ChEBI:CHEBI:57306, ChEBI:CHEBI:60344; EC=4.98.1.1; |
| PATHWAY | Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. |
| end case | |
| case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella> | |
| SUBUNIT | Monomer. |
| end case | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the ferrochelatase family. |
Keywords
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Gene Ontology
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| GO:0004325; Molecular function:ferrochelatase activity |
| GO:0006783; Biological process:heme biosynthetic process |
| GO:0006779; Biological process:porphyrin-containing compound biosynthetic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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| From: CPFC_LISMO (Q8Y565) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 182 | 182 | /ligand="Fe(2+)" /ligand_id="ChEBI:CHEBI:29033" |
H | ||||||||
| BINDING | 263 | 263 | /ligand="Fe(2+)" /ligand_id="ChEBI:CHEBI:29033" |
E | ||||||||
| case <OC:Bacillota> or <OC:Actinomycetota> | ||||||||||||
| BINDING | 45 | 46 | /ligand="Fe-coproporphyrin III" /ligand_id="ChEBI:CHEBI:68438" |
R-Y | ||||||||
| BINDING | 12 | 12 | /ligand="Fe-coproporphyrin III" /ligand_id="ChEBI:CHEBI:68438" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue" |
Y | ||||||||
| BINDING | 29 | 29 | /ligand="Fe-coproporphyrin III" /ligand_id="ChEBI:CHEBI:68438" |
R | ||||||||
| BINDING | 53 | 53 | /ligand="Fe-coproporphyrin III" /ligand_id="ChEBI:CHEBI:68438" |
S | ||||||||
| BINDING | 124 | 124 | /ligand="Fe-coproporphyrin III" /ligand_id="ChEBI:CHEBI:68438" |
Y | ||||||||
| end case | ||||||||||||
Additional information
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| Size range | 303-391 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |