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HAMAP rule MF_00323

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General rule information [?]

Accession MF_00323
Dates 1-JUN-2001 (Created)
2-SEP-2024 (Last updated, Version 49)
Name Ferrochelatase
Scope(s) Bacteria
Archaea
Template(s) P32396 (CPFC_BACSU); P23871 (HEMH_ECOLI); Q8Y565 (CPFC_LISMO); [ Recover all ]
Triggered by HAMAP; MF_00323 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Bacillota> or <OC:Actinomycetota>
Identifier CPFC
Protein name RecName: Full=Coproporphyrin III ferrochelatase;
                 EC=4.99.1.9;
Gene name Name=cpfC;
else
Identifier HEMH
Protein name RecName: Full=Ferrochelatase;
                 EC=4.98.1.1;
AltName: Full=Heme synthase;
AltName: Full=Protoheme ferro-lyase;
Gene name Name=hemH;
end case

Comments [?]

case <OC:Bacillota> or <OC:Actinomycetota>
FUNCTIONInvolved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.
CATALYTIC ACTIVITY Reaction=Fe-coproporphyrin III + 2 H(+) = coproporphyrin III + Fe(2+); Xref=Rhea:RHEA:49572, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033, ChEBI:CHEBI:68438, ChEBI:CHEBI:131725; EC=4.99.1.9; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:49574;
PATHWAYPorphyrin-containing compound metabolism; protoheme biosynthesis.
else
FUNCTIONCatalyzes the ferrous insertion into protoporphyrin IX.
CATALYTIC ACTIVITY Reaction=heme b + 2 H(+) = protoporphyrin IX + Fe(2+); Xref=Rhea:RHEA:22584, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033, ChEBI:CHEBI:57306, ChEBI:CHEBI:60344; EC=4.98.1.1;
PATHWAYPorphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.
end case
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
SUBUNITMonomer.
end case
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the ferrochelatase family.

Keywords [?]


Gene Ontology [?]

GO:0004325; Molecular function:ferrochelatase activity
GO:0006783; Biological process:heme biosynthetic process
GO:0006779; Biological process:porphyrin-containing compound biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00762; Ferrochelatase; 1;
NCBIfam TIGR00109; HemH; 1;
PROSITE PS00534; FERROCHELATASE; 1;

Features [?]

From: CPFC_LISMO (Q8Y565)
Key From To Description Tag Condition FTGroup
BINDING 182 182 /ligand="Fe(2+)"
/ligand_id="ChEBI:CHEBI:29033"
H
BINDING 263 263 /ligand="Fe(2+)"
/ligand_id="ChEBI:CHEBI:29033"
E
case <OC:Bacillota> or <OC:Actinomycetota>
BINDING 45 46 /ligand="Fe-coproporphyrin III"
/ligand_id="ChEBI:CHEBI:68438"
R-Y
BINDING 12 12 /ligand="Fe-coproporphyrin III"
/ligand_id="ChEBI:CHEBI:68438"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="axial binding residue"
Y
BINDING 29 29 /ligand="Fe-coproporphyrin III"
/ligand_id="ChEBI:CHEBI:68438"
R
BINDING 53 53 /ligand="Fe-coproporphyrin III"
/ligand_id="ChEBI:CHEBI:68438"
S
BINDING 124 124 /ligand="Fe-coproporphyrin III"
/ligand_id="ChEBI:CHEBI:68438"
Y
end case

Additional information [?]

Size range 303-391 amino acids
Related rules None
Fusion Nter: None Cter: None



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