HAMAP

Accession	MF_00323
Dates	1-JUN-2001 (Created) 19-SEP-2011 (Last updated, Version 36)

Data class

Protein

Predictors

HAMAP; MF_00323; [distribution of match scores in UniProtKB];[seed alignment for MF_00323]

Names

Ferrochelatase

Identifier

HEMH

Protein name

RecName: Full=Ferrochelatase; EC=4.99.1.1; AltName: Full=Heme synthase; AltName: Full=Protoheme ferro-lyase;

Gene name

hemH

FUNCTION: Catalyzes the ferrous insertion into protoporphyrin IX (By similarity).

CATALYTIC ACTIVITY: Protoheme + 2 H(+) = protoporphyrin + Fe(2+).

PATHWAY: Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.

SUBUNIT: Monomer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the ferrochelatase family.

Pfam	PF00762; Ferrochelatase; 1;
TIGRFAMs	TIGR00109; HemH; 1;
PROSITE	PS00534; FERROCHELATASE; 1;

Cytoplasm, Porphyrin biosynthesis, Heme biosynthesis, Lyase, Iron, Metal-binding.

GO:0004325; Molecular function: ferrochelatase activity.
GO:0006783; Biological process: heme biosynthetic process.
GO:0006779; Biological process: porphyrin-containing compound biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

From: HEMH_BACSU (P32396)
Key		From		To		Description		Condition		FTGroup
METAL		183		183		Iron (By similarity)		H
METAL		264		264		Iron (By similarity)		E

Size range:	303-391 amino acids
Related UniRules:	None
Template:	P32396 (HEMH_BACSU); P23871 (HEMH_ECOLI): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in BACAN, BACCR, SHEON
Plasmid encoded:	None