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HAMAP annotation rule: MF_00332
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General rule information

Accession MF_00332
Dates 1-JUN-2001 (Created)
14-FEB-2011 (Last updated, Version 48)
Data class Protein
Predictors HAMAP; MF_00332; [distribution of match scores in UniProtKB];[seed alignment for MF_00332]
Names DnaK


Propagated annotation

Identifier, protein and gene names
Identifier DNAK
Protein name
RecName: Full=Chaperone protein DnaK;
AltName: Full=HSP70;
AltName: Full=Heat shock 70 kDa protein;
AltName: Full=Heat shock protein 70;
Gene name dnaK
Comments
FUNCTION: Acts as a chaperone (By similarity).

case <OC:Bacteria>
INDUCTION: By stress conditions e.g. heat shock (By similarity).
end case


case <OG:Chloroplast>
SUBCELLULAR LOCATION: Plastid, chloroplast (By similarity).
end case

SIMILARITY: Belongs to the heat shock protein 70 family.
Cross-references
Pfam PF00012; HSP70; 1;
PRINTS PR00301; HEATSHOCK70; 1;
PROSITE PS00297; HSP70_1; 1;
PS00329; HSP70_2; 1;
PS01036; HSP70_3; 1;
Keywords

case <FT:2> or <FT:3> or <FT:4> or <FT:5> or <FT:6>
Acetylation.
end case

ATP-binding, Chaperone, Nucleotide-binding.

case <OC:Bacteria>
Stress response.
end case


case <OC:Bacteria> and <FT:1>
Phosphoprotein.
end case

Gene Ontology
GO:0005524; Molecular function: ATP binding.

case <OG:Chloroplast>
GO:0009507; Cellular component: chloroplast.
end case

Features

case <OC:Bacteria>
From: DNAK_ECOLI (P0A6Y8)
Key     From     To       Description   Condition   FTGroup
MOD_RES     199     199       Phosphothreonine; by autocatalysis (By similarity)   T  
end case

case <OC:Escherichia> or <OC:Shigella>
Key     From     To       Description   Condition   FTGroup
MOD_RES     109     109       N6-acetyllysine (By similarity)   K  
MOD_RES     245     245       N6-acetyllysine (By similarity)   K  
MOD_RES     304     304       N6-acetyllysine (By similarity)   K  
MOD_RES     421     421       N6-acetyllysine (By similarity)   K  
MOD_RES     556     556       N6-acetyllysine (By similarity)   K  
end case



Additional information

Size range: 591-771 amino acids
Related UniRules: MF_00679 (HSCA)
Template: P0A6Y8 (DNAK_ECOLI)
Scope: Bacteria
Archaea
Plastid
Fusion: Nter: None; Cter: None
Duplicate: in NOSS1, PROMA, PROMM, PROMP, STRAW, THEEB, SYNE7, SYNPX, SYNY3
Plasmid encoded: None
Comments: Cyanobacteria have 3 copies of dnaK, only the second one (dnaK2) is represented in this alignment. The two others are divergent and longer

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UniProtKB rule member sequences