To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https
Annotation rule MF_00332
Send feedback

General rule information [?]

Accession MF_00332
Dates 1-JUN-2001 (Created)
24-JUN-2016 (Last updated, Version 50)
Name DnaK
Scope Bacteria
Template P0A6Y8 (DNAK_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Chaperone protein DnaK;
AltName: Full=HSP70;
AltName: Full=Heat shock 70 kDa protein;
AltName: Full=Heat shock protein 70;
Gene name

Comments [?]

Function Acts as a chaperone.
case <OC:Bacteria>
Induction By stress conditions e.g. heat shock.
end case
case <OG:Chloroplast>
Subcellular location Plastid, chloroplast.
end case
Similarity Belongs to the heat shock protein 70 family.

Keywords [?]

case <FT:2> or <FT:3> or <FT:4> or <FT:5> or <FT:6>
end case
case <OC:Bacteria>
end case
case <OC:Bacteria> and <FT:1>
end case

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
case <OG:Chloroplast>
GO:0009507; Cellular component: chloroplast.
end case

Cross-references [?]

Pfam PF00012; HSP70; 1;
PROSITE PS00297; HSP70_1; 1;
PS00329; HSP70_2; 1;
PS01036; HSP70_3; 1;
TIGRFAMs TIGR02350; prok_dnaK; 1;

Features [?]

case <OC:Bacteria>
Key     From     To       Description   Tag   Condition   FTGroup
MOD_RES     199     199       Phosphothreonine; by autocatalysis     T  
end case
case <OC:Escherichia> or <OC:Shigella>
MOD_RES     109     109       N6-acetyllysine     K  
MOD_RES     245     245       N6-acetyllysine     K  
MOD_RES     304     304       N6-acetyllysine     K  
MOD_RES     421     421       N6-acetyllysine     K  
MOD_RES     556     556       N6-acetyllysine     K  
end case

Additional information [?]

Size range 591-771 amino acids
Related rules MF_00679 (HSCA)
Fusion None
Comments Cyanobacteria have 3 copies of dnaK, only the second one (dnaK2) is represented in this alignment. The two others are divergent and longer