HAMAP

Accession	MF_00333
Dates	1-JUN-2001 (Created) 19-SEP-2011 (Last updated, Version 34)

Data class

Protein

Predictors

HAMAP; MF_00333; [distribution of match scores in UniProtKB];[seed alignment for MF_00333]

Names

Coprogen_oxidas

Identifier

HEM6

Protein name

RecName: Full=Coproporphyrinogen-III oxidase, aerobic; Short=Coprogen oxidase; Short=Coproporphyrinogenase; EC=1.3.3.3;

Gene name

hemF

FUNCTION: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity).

CATALYTIC ACTIVITY: Coproporphyrinogen-III + O(2) + 2 H(+) = protoporphyrinogen-IX + 2 CO(2) + 2 H(2)O.

COFACTOR: Manganese (By similarity).

PATHWAY: Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.

SUBUNIT: Homodimer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the aerobic coproporphyrinogen-III oxidase family.

Pfam	PF01218; Coprogen_oxidas; 1;
PRINTS	PR00073; COPRGNOXDASE; 1;
PROSITE	PS01021; COPROGEN_OXIDASE; 1;

Cytoplasm, Porphyrin biosynthesis, Oxidoreductase.

Manganese.

GO:0004109; Molecular function: coproporphyrinogen oxidase activity.
GO:0042803; Molecular function: protein homodimerization activity.
GO:0006779; Biological process: porphyrin-containing compound biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

From: HEM6_ECOLI (P36553)
Key		From		To		Description		Condition		FTGroup
REGION		48		57		Important for dimerization (By similarity)		x-[ILMV]-x(2)-[DG]-x(2)-[FIL]-E-[KQR]		1
REGION		108		110		Substrate binding (By similarity)		N-x-R
REGION		240		275		Important for dimerization (By similarity)		Y-x-E-[FY]-N-L-[ILV]-x-D-R-G-T-x-F-G-[IL]-x(3)-G-x(2)-[DEN]-[AS]-[IV]-L-x-S-[LM]-P-P-x(3)-[FW]-x		1
REGION		258		263		Substrate binding (By similarity)		x-[GS]-[NR]-x(2)-[AS]
ACT_SITE		106		106		Proton donor (By similarity)		H
BINDING		92		92		Substrate (By similarity)		S
SITE		175		175		Important for dimerization (By similarity)		H

Size range:	279-363 amino acids
Related UniRules:	None
Template:	P36553 (HEM6_ECOLI)
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	in NOSS1
Plasmid encoded:	None