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HAMAP annotation rule: MF_00339
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General rule information

Accession MF_00339
Dates 1-JUN-2001 (Created)
4-JAN-2011 (Last updated, Version 29)
Data class Protein
Predictors HAMAP; MF_00339; [distribution of match scores in UniProtKB];[seed alignment for MF_00339]
Names Phosphofructokinase


Propagated annotation

Identifier, protein and gene names
Identifier K6PF
Protein name
RecName: Full=6-phosphofructokinase;
Short=Phosphofructokinase;
EC=2.7.1.11;
AltName: Full=Phosphohexokinase;
Gene name pfkA
Comments
CATALYTIC ACTIVITY: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.
PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the phosphofructokinase family.
Cross-references
Pfam PF00365; PFK; 1;
PRINTS PR00476; PHFRCTKINASE; 1;
PROSITE PS00433; PHOSPHOFRUCTOKINASE; 1;
Keywords
Cytoplasm, Kinase, Transferase, Glycolysis, ATP-binding, Nucleotide-binding.

case <FTGroup:1>
Magnesium, Metal-binding.
end case

Gene Ontology
GO:0003872; Molecular function: 6-phosphofructokinase activity.
GO:0006096; Biological process: glycolysis.
GO:0005737; Cellular component: cytoplasm.
Features
From: K6PF_GEOSE (P00512)
Key     From     To       Description   Condition   FTGroup
NP_BIND     21     25       ATP (By similarity)      
NP_BIND     154     158       ATP (By similarity)      
NP_BIND     171     187       ATP (By similarity)      
ACT_SITE     127     127       Proton acceptor (By similarity)   D  
 
METAL     185     185       Magnesium; via carbonyl oxygen (By similarity)   G   1
METAL     187     187       Magnesium (By similarity)   [DE]   1
 
BINDING     162     162       Substrate (By similarity)      
BINDING     243     243       Substrate (By similarity)      
BINDING     249     249       Substrate (By similarity)   [HY]  
BINDING     252     252       Substrate (By similarity)   R  


Additional information

Size range: 319-361 amino acids
Related UniRules: None
Template: P00512 (K6PF_GEOSE)
Scope: Bacteria
Fusion: Nter: None; Cter: None
Duplicate: in NOSS1, BACTN, CLOPE, STRCO, SYNY3
Plasmid encoded: None
Comments: Possible wrong starts in DEIRA and UREPA. XYLFA has a highly divergent pfkA; Xf0274. It is currently not possible to distinguish a real pfKA from a pyrophosphate--fructose 6-phosphate 1-phosphotransferase (EC 2.7.1.90) (pfp).

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UniProtKB rule member sequences