HAMAP

Accession	MF_00345
Dates	1-JUN-2001 (Created) 9-JUN-2011 (Last updated, Version 26)

Data class

Protein

Predictors

HAMAP; MF_00345; [distribution of match scores in UniProtKB];[seed alignment for MF_00345]

Names

GMP_synthase_B

Identifier

GUAAB

Protein name

RecName: Full=GMP synthase [glutamine-hydrolyzing] subunit B; EC=6.3.5.2; AltName: Full=GMP synthetase;

Gene name

guaAB

FUNCTION: Catalyzes the synthesis of GMP from XMP (By similarity).

CATALYTIC ACTIVITY: ATP + xanthosine 5'-phosphate + L-glutamine + H(2)O = AMP + diphosphate + GMP + L-glutamate.

PATHWAY: Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.

SUBUNIT: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B) (Potential).

SIMILARITY: Contains 1 GMP-binding domain.

Pfam	PF00958; GMP_synt_C; 1;
TIGRFAMs	TIGR00884; GuaA_Cterm; 1;

Ligase, GMP biosynthesis, Purine biosynthesis, ATP-binding, Nucleotide-binding.

GO:0005524; Molecular function: ATP binding.
GO:0003922; Molecular function: GMP synthase (glutamine-hydrolyzing) activity.
GO:0006177; Biological process: GMP biosynthetic process.

From: GUAAB_METJA (Q58531)
Key		From		To		Description		Condition		FTGroup
DOMAIN		33		186		GMP-binding
NP_BIND		29		35		ATP (By similarity)		S-G-G-x-D-S-[ST]

Size range:	303-370 amino acids
Related UniRules:	MF_00344 (GUAA (supersedes the current rule))
Template:	P04079 (GUAA_ECOLI)
Scope:	Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	Sequences from AERPE and PYRAE are like that of Eubacteria composed of two domains, while other archaea have separate proteins that correspond to each domain