HAMAP rule MF_00347
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_00347 |
| Accession | MF_00347 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 33) |
| Name | Polyphosphate_kinase |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P0A7B1 (PPK1_ECOLI); Q07411 (PPK1_KLEPN); Q9JXS9 (PPK1_NEIMB); [ Recover all ] |
| Triggered by |
HAMAP; MF_00347 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PPK1 |
| Protein name | RecName: Full=Polyphosphate kinase; EC=2.7.4.1; AltName: Full=ATP-polyphosphate phosphotransferase; AltName: Full=Polyphosphoric acid kinase; |
| Gene name | Name=ppk; |
Comments
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| FUNCTION | Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). |
| CATALYTIC ACTIVITY | Reaction=[phosphate](n) + ATP = [phosphate](n+1) + ADP; Xref=Rhea:RHEA:19573, Rhea:RHEA-COMP:9859, Rhea:RHEA-COMP:14280, ChEBI:CHEBI:16838, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216; EC=2.7.4.1; |
| case <FTGroup:1> | |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| end case | |
| PTM | An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond. |
| SIMILARITY | Belongs to the polyphosphate kinase 1 (PPK1) family. |
Keywords
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| ATP-binding | |
| Kinase | |
| case <FTGroup:1> | |
| Magnesium | |
| Metal-binding | |
| end case | |
| Nucleotide-binding | |
| Phosphoprotein | |
| Transferase | |
Gene Ontology
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| GO:0008976; Molecular function:polyphosphate kinase activity |
| GO:0006799; Biological process:polyphosphate biosynthetic process |
Cross-references
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| Pfam | PF02503; PP_kinase; 1; |
| Pfam | PF13090; PP_kinase_C; 1; |
| Pfam | PF13089; PP_kinase_N; 1; |
| PIRSF | PIRSF015589; PP_kinase; 1; |
| NCBIfam | TIGR03705; poly_P_kin; 1; |
| PROSITE | PS50035; PLD; 0-1; |
Features
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| From: PPK1_ECOLI (P0A7B1) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 435 | 435 | /note="Phosphohistidine intermediate" | H | ||||||||
| BINDING | 375 | 375 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
R | 1 | |||||||
| BINDING | 405 | 405 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
R | 1 | |||||||
| BINDING | 45 | 45 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
N | ||||||||
| BINDING | 468 | 468 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
Y | ||||||||
| BINDING | 564 | 564 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
R | ||||||||
| BINDING | 592 | 592 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
H | ||||||||
Additional information
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| Size range | 640-850 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |