HAMAP annotation rule MF_00351
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Accession MF_00351
Dates 1-JUN-2001 (Created)
6-JUL-2012 (Last updated, Version 14)
Name RNA_methyltransf_FlpA
Scope Archaea
Triggered by



Identifier
FLPA
Protein name
RecName: Full=Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase;
EC=2.1.1.-;
Gene name
flpA


FUNCTION Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity).
SUBUNIT Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA (By similarity).
SIMILARITY Belongs to the methyltransferase superfamily. Fibrillarin family.


Methyltransferase
RNA-binding
rRNA processing
Transferase
tRNA processing


GO:0003723; Molecular function: RNA binding.
GO:0008168; Molecular function: methyltransferase activity.
GO:0006364; Biological process: rRNA processing.
GO:0008033; Biological process: tRNA processing.


Pfam PF01269; Fibrillarin; 1;
PRINTS PR00052; FIBRILLARIN; 1;
PROSITE PS00566; FIBRILLARIN; 1;


From: FLPA_ARCFU (O28192)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     70     71       S-adenosyl-L-methionine binding (By similarity)     T-T  
REGION     88     89       S-adenosyl-L-methionine binding (By similarity)     E-x  
REGION     113     114       S-adenosyl-L-methionine binding (By similarity)     D-A  
BINDING     42     42       S-adenosyl-L-methionine (By similarity)     K  
BINDING     133     133       S-adenosyl-L-methionine (By similarity)     D  


Size range: 200-235 amino acids
Related Rules: None
Templates: O28192 (FLPA_ARCFU); P58032 (FLPA_SULSO); Q58108 (FLPA_METJA); Q8U4M2 (FLPA_PYRFU): [Recover all]
Fusion: None
Comments: The "x" in the condition of the second S-adenosyl-L-methionine-binding region most often is a large and hydrophobic residue (pi-stacking interaction).


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