To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https
Annotation rule MF_00351
Send feedback

General rule information [?]

Accession MF_00351
Dates 1-JUN-2001 (Created)
26-SEP-2014 (Last updated, Version 16)
Name RNA_methyltransf_FlpA
Scope Archaea
Templates O28192 (FLPA_ARCFU); P58032 (FLPA_SULSO); Q58108 (FLPA_METJA); Q8U4M2 (FLPA_PYRFU); Q9Y9U3 (FLPA_AERPE): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase;
Gene name

Comments [?]

Function Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.
Subunit Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
Similarity Belongs to the methyltransferase superfamily. Fibrillarin family.

Keywords [?]

Gene Ontology [?]

GO:0003723; Molecular function: RNA binding.
GO:0008168; Molecular function: methyltransferase activity.
GO:0006364; Biological process: rRNA processing.
GO:0008033; Biological process: tRNA processing.

Cross-references [?]

Pfam PF01269; Fibrillarin; 1;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
REGION     90     91       S-adenosyl-L-methionine binding     [TS]-T  
REGION     109     110       S-adenosyl-L-methionine binding     [ED]-x  
REGION     134     135       S-adenosyl-L-methionine binding     [DN]-[AS]  
REGION     154     157       S-adenosyl-L-methionine binding     D-[IVL]-[SA]-[QT]  

Additional information [?]

Size range 185-245 amino acids
Related rules None
Fusion None
Comments The "x" in the condition of the second S-adenosyl-L-methionine-binding region most often is a large and hydrophobic residue (pi-stacking interaction).