HAMAP

Accession	MF_00351
Dates	1-JUN-2001 (Created) 20-NOV-2009 (Last updated, Version 13)

Data class

Protein

Predictors

HAMAP; MF_00351; [distribution of match scores in UniProtKB];[seed alignment for MF_00351]

Names

RNA_methyltransf_FlpA

Identifier

FLPA

Protein name

RecName: Full=Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase; EC=2.1.1.-;

Gene name

flpA

FUNCTION: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity).

SUBUNIT: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, flpA and nop5, plus a guide RNA (By similarity).

SIMILARITY: Belongs to the methyltransferase superfamily. Fibrillarin family.

Pfam	PF01269; Fibrillarin; 1;
PRINTS	PR00052; FIBRILLARIN; 1;
PROSITE	PS00566; FIBRILLARIN; 1;

Methyltransferase, RNA-binding, rRNA processing, Transferase, tRNA processing.

GO:0003723; Molecular function: RNA binding.
GO:0008168; Molecular function: methyltransferase activity.
GO:0006364; Biological process: rRNA processing.
GO:0008033; Biological process: tRNA processing.

From: FLPA_ARCFU (O28192)
Key		From		To		Description		Condition		FTGroup
REGION		70		71		S-adenosyl-L-methionine binding (By similarity)		T-T
REGION		88		89		S-adenosyl-L-methionine binding (By similarity)		E-x
REGION		113		114		S-adenosyl-L-methionine binding (By similarity)		D-A
BINDING		42		42		S-adenosyl-L-methionine (By similarity)		K
BINDING		133		133		S-adenosyl-L-methionine (By similarity)		D

Size range:	200-235 amino acids
Related UniRules:	None
Template:	O28192 (FLPA_ARCFU); P58032 (FLPA_SULSO); Q58108 (FLPA_METJA); Q8U4M2 (FLPA_PYRFU): [Recover all]
Scope:	Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	The "x" in the condition of the second S-adenosyl-L-methionine-binding region most often is a large and hydrophobic residue (pi-stacking interaction).