HAMAP rule MF_00364
General rule information
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Accession | MF_00364 |
Dates | 1-JUN-2001 (Created)
26-JAN-2023 (Last updated, Version 30) |
Name | NagZ |
Scope(s) |
Bacteria Pseudomonadota |
Template(s) | P75949 (NAGZ_ECOLI); Q8ZQ06 (NAGZ_SALTY); Q9KU37 (NAGZ_VIBCH); [ Recover all ] |
Triggered by |
HAMAP; MF_00364 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | NAGZ |
Protein name | RecName: Full=Beta-hexosaminidase; EC=3.2.1.52; AltName: Full=Beta-N-acetylhexosaminidase; AltName: Full=N-acetyl-beta-glucosaminidase; |
Gene name | Name=nagZ; |
Comments
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FUNCTION | Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. |
CATALYTIC ACTIVITY | Reaction=Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.; EC=3.2.1.52; |
PATHWAY | Cell wall biogenesis; peptidoglycan recycling. |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. |
Keywords
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Cell cycle |
Cell division |
Cell shape |
Cell wall biogenesis/degradation |
Cytoplasm |
Glycosidase |
Hydrolase |
Peptidoglycan synthesis |
Gene Ontology
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GO:0004563; Molecular function:beta-N-acetylhexosaminidase activity |
GO:0009254; Biological process:peptidoglycan turnover |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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From: NAGZ_SALTY (Q8ZQ06) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 163 | 164 | /ligand="substrate" | K-H | ||||||||
ACT_SITE | 176 | 176 | /note="Proton donor/acceptor" | H | ||||||||
ACT_SITE | 248 | 248 | /note="Nucleophile" | D | ||||||||
BINDING | 62 | 62 | /ligand="substrate" | D | ||||||||
BINDING | 70 | 70 | /ligand="substrate" | R | ||||||||
BINDING | 133 | 133 | /ligand="substrate" | R | ||||||||
SITE | 174 | 174 | /note="Important for catalytic activity" | D |
Additional information
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Size range | 300-400 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |