HAMAP rule MF_00367
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_00367 |
| Accession | MF_00367 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 41) |
| Name | GTPase_Era |
| Scope(s) |
Bacteria |
| Template(s) | P06616 (ERA_ECOLI); O67800 (ERA_AQUAE); P37214 (ERA_STRMU); P42182 (ERA_BACSU); P0A3C4 (ERA_STRR6); Q5SM23 (ERA_THET8); A5U557 (ERA_MYCTA); A0R0S7 (ERA_MYCS2); [ Recover all ] |
| Triggered by |
HAMAP; MF_00367 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ERA |
| Protein name | RecName: Full=GTPase Era; |
| Gene name | Name=era; |
Comments
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| case not <OC:Mycobacteriaceae> | |
| FUNCTION | An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. |
| else case <OC:Mycobacteriaceae> | |
| FUNCTION | Exhibits GTPase activity. Binds RNA but is probably not involved in ribosome assembly in mycobacteria. |
| end case | |
| SUBUNIT | Monomer. |
| case <OC:Mycobacteriaceae> | |
| SUBCELLULAR LOCATION | Cell envelope. Secreted, cell wall. |
| else case not defined <Property:Membrane> or <Property:Membrane=1> | |
| SUBCELLULAR LOCATION | Cytoplasm. Cell membrane; Peripheral membrane protein. |
| else case <Property:Membrane=2> | |
| SUBCELLULAR LOCATION | Cytoplasm. Cell inner membrane; Peripheral membrane protein. |
| end case | |
| SIMILARITY | Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family. |
Keywords
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| GTP-binding | |
| Nucleotide-binding | |
| RNA-binding | |
| case not <OC:Mycobacteriaceae> | |
| Cell membrane | |
| Cytoplasm | |
| Membrane | |
| Ribosome biogenesis | |
| rRNA-binding | |
| end case | |
| case (defined <Property:Membrane> and <Property:Membrane=2>) and not <OC:Mycobacteriaceae> | |
| Cell inner membrane | |
| end case | |
| case <OC:Mycobacteriaceae> | |
| Cell wall | |
| Secreted | |
| end case | |
Gene Ontology
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| GO:0005525; Molecular function:GTP binding | |
| GO:0003924; Molecular function:GTPase activity | |
| case not <OCellular component:Mycobacteriaceae> | |
| GO:0070181; Molecular function:small ribosomal subunit rRNA binding | |
| GO:0042274; Biological process:ribosomal small subunit biogenesis | |
| GO:0005737; Cellular component:cytoplasm | |
| GO:0005886; Cellular component:plasma membrane | |
| end case | |
Cross-references
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| Pfam | PF07650; KH_2; 1; |
| Pfam | PF01926; MMR_HSR1; 1; |
| PRINTS | PR00326; GTP1OBG; 1; |
| NCBIfam | TIGR00436; Era; 1; |
| NCBIfam | TIGR00231; Small_GTP; 1; |
| PROSITE | PS50823; KH_TYPE_2; 1; |
| PROSITE | PS51713; G_ERA; 1; |
Features
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| From: ERA_ECOLI (P06616) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 15 | 22 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" |
G-x-[PTA]-x-x-G-K-S | ||||||||
| BINDING | 62 | 66 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" |
D-[TV]-P-G-x | ||||||||
| BINDING | 124 | 127 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" |
x-K-x-x | ||||||||
Additional information
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| Size range | 278-325 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | RICCN has an RPE1 insert in its N-terminus and so is considered atypical. |