HAMAP

Accession	MF_00367
Dates	1-JUN-2001 (Created) 9-JUN-2011 (Last updated, Version 31)

Data class

Protein

Predictors

HAMAP; MF_00367; [distribution of match scores in UniProtKB];[seed alignment for MF_00367]

Names

GTPase_Era

Identifier

ERA

Protein name

RecName: Full=GTPase Era;

Gene name

era

FUNCTION: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity).

SUBUNIT: Monomer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm. Cell membrane; Peripheral membrane protein (By similarity).

SUBCELLULAR LOCATION: Cytoplasm. Cell inner membrane; Peripheral membrane protein (By similarity).

SIMILARITY: Belongs to the Era/MnmE GTP-binding protein family. Era subfamily.

SIMILARITY: Contains 1 KH type-2 domain.

Pfam	PF07650; KH_2; 1; PF01926; MMR_HSR1; 1; trigger=Yes;
PRINTS	PR00326; GTP1OBG; 1;
TIGRFAMs	TIGR00436; Era; 1; TIGR00231; Small_GTP; 1;
PROSITE	PS50823; KH_TYPE_2; 1; trigger=PRU00118;

GTP-binding, Nucleotide-binding, Ribosome biogenesis.

RNA-binding, rRNA-binding.

Cytoplasm.

Cell inner membrane.

Cell membrane, Membrane.

GO:0005525; Molecular function: GTP binding.
GO:0003924; Molecular function: GTPase activity.
GO:0070181; Molecular function: SSU rRNA binding.
GO:0042274; Biological process: ribosomal small subunit biogenesis.
GO:0005737; Cellular component: cytoplasm.
GO:0005886; Cellular component: plasma membrane.

From: ERA_ECOLI (P06616)
Key		From		To		Description		Condition		FTGroup
NP_BIND		15		22		GTP (Potential)		G-x-[PTA]-x-x-G-K-S
NP_BIND		62		66		GTP (Potential)		D-[TV]-P-G-x
NP_BIND		124		127		GTP (Potential)		x-K-x-x

Size range:	278-325 amino acids
Related UniRules:	None
Template:	P06616 (ERA_ECOLI); O67800 (ERA_AQUAE); P37214 (ERA_STRMU); P42182 (ERA_BACSU); P0A3C4 (ERA_STRR6); Q5SM23 (ERA_THET8): [Recover all]
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	RICCN has an RPE1 insert in its N-terminus and so is considered atypical.