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HAMAP annotation rule: MF_00372
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General rule information

Accession MF_00372
Dates 1-JUN-2001 (Created)
9-DEC-2011 (Last updated, Version 23)
Data class Protein
Predictors HAMAP; MF_00372; [distribution of match scores in UniProtKB];[seed alignment for MF_00372]
Names HutI


Propagated annotation

Identifier, protein and gene names
Identifier HUTI

case <OC:Bacteria>
Protein name
RecName: Full=Imidazolonepropionase;
EC=3.5.2.7;
AltName: Full=Imidazolone-5-propionate hydrolase;
end case


case <OC:Archaea>
Protein name
RecName: Full=Probable imidazolonepropionase;
EC=3.5.2.7;
AltName: Full=Imidazolone-5-propionate hydrolase;
end case

Gene name hutI
Comments
CATALYTIC ACTIVITY: (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H(2)O = N-formimidoyl-L-glutamate + H(+).

case <FTGroup:1>
COFACTOR: Binds 1 zinc or iron ion per subunit (By similarity).
end case

PATHWAY: Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3.
SUBCELLULAR LOCATION: Cytoplasm (Potential).
SIMILARITY: Belongs to the HutI family.
Cross-references
Pfam PF01979; Amidohydro_1; 1;
TIGRFAMs TIGR01224; HutI; 1;
Keywords
Cytoplasm, Hydrolase, Histidine metabolism.

case <FTGroup:1>
Metal-binding, Iron, Zinc.
end case

Gene Ontology
GO:0050480; Molecular function: imidazolonepropionase activity.
GO:0006548; Biological process: histidine catabolic process.

case <FTGroup:1>
GO:0005506; Molecular function: iron ion binding.
GO:0008270; Molecular function: zinc ion binding.
end case

GO:0005737; Cellular component: cytoplasm.
Features
From: HUTI_BACSU (P42084)
Key     From     To       Description   Condition   FTGroup
METAL     80     80       Zinc or iron (By similarity)   H   1
METAL     82     82       Zinc or iron (By similarity)   H   1
METAL     249     249       Zinc or iron (By similarity)   H   1
METAL     324     324       Zinc or iron (By similarity)   [DN]   1
 
BINDING     89     89       Substrate (By similarity)   R  
BINDING     102     102       Substrate (By similarity)   Y  
BINDING     152     152       Substrate (By similarity)   Y  
BINDING     185     185       Substrate (By similarity)   H  
BINDING     252     252       Substrate (By similarity)   [EQ]  


Additional information

Size range: 388-456 amino acids
Related UniRules: None
Template: P42084 (HUTI_BACSU); Q8U8Z6 (HUTI_AGRT5): [Recover all]
Scope: Bacteria
Archaea
Fusion: Nter: <Unknown>; Cter: MF_00229 (hutH)
Duplicate: None
Plasmid encoded: in AGRRH, RHIME

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UniProtKB rule member sequences