HAMAP rule MF_00375
General rule information
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| Accession | MF_00375 |
| Dates | 1-JUN-2001 (Created)
15-FEB-2024 (Last updated, Version 53) |
| Name | HemL_aminotrans_3 |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P23893 (GSA_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00375 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | GSA |
| Protein name | RecName: Full=Glutamate-1-semialdehyde 2,1-aminomutase; Short=GSA; EC=5.4.3.8; AltName: Full=Glutamate-1-semialdehyde aminotransferase; Short=GSA-AT; |
| Gene name | Name=hemL; |
Comments
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| CATALYTIC ACTIVITY | Reaction=(S)-4-amino-5-oxopentanoate = 5-aminolevulinate; Xref=Rhea:RHEA:14265, ChEBI:CHEBI:57501, ChEBI:CHEBI:356416; EC=5.4.3.8; |
| COFACTOR | Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; |
| case not <Property:PHOTOSYN> | |
| PATHWAY | Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2. |
| end case | |
| case <Property:PHOTOSYN> | |
| PATHWAY | Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2. |
| PATHWAY | Porphyrin-containing compound metabolism; chlorophyll biosynthesis. |
| end case | |
| case <OC:Bacteria> | |
| SUBUNIT | Homodimer. |
| end case | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. |
Keywords
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| Cytoplasm | |
| Porphyrin biosynthesis | |
| case <Property:PHOTOSYN> | |
| Chlorophyll biosynthesis | |
| end case | |
| Isomerase | |
| Pyridoxal phosphate | |
Gene Ontology
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| GO:0042286; Molecular function:glutamate-1-semialdehyde 2,1-aminomutase activity | |
| case <Property:PHOTOSYN> | |
| GO:0015995; Biological process:chlorophyll biosynthetic process | |
| end case | |
| GO:0006782; Biological process:protoporphyrinogen IX biosynthetic process | |
| GO:0005737; Cellular component:cytoplasm | |
Cross-references
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Features
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| From: GSA_ECOLI (P23893) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOD_RES | 265 | 265 | /note="N6-(pyridoxal phosphate)lysine" | K | ||||||||
Additional information
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| Size range | 412-466 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | A third putative copy exists in HALH5. A second divergent copy exists in AERPE. |