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HAMAP annotation rule: MF_00375
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General rule information

Accession MF_00375
Dates 1-JUN-2001 (Created)
19-SEP-2011 (Last updated, Version 38)
Data class Protein
Predictors HAMAP; MF_00375; [distribution of match scores in UniProtKB];[seed alignment for MF_00375]
Names HemL_aminotrans_3


Propagated annotation

Identifier, protein and gene names
Identifier GSA
Protein name
RecName: Full=Glutamate-1-semialdehyde 2,1-aminomutase;
Short=GSA;
EC=5.4.3.8;
AltName: Full=Glutamate-1-semialdehyde aminotransferase;
Short=GSA-AT;
Gene name hemL
Comments
CATALYTIC ACTIVITY: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.
COFACTOR: Pyridoxal phosphate (By similarity).

case not <Property:PHOTOSYN>
PATHWAY: Porphyrin metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.
end case


case <Property:PHOTOSYN>
PATHWAY: Porphyrin metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.
PATHWAY: Porphyrin biosynthesis; chlorophyll biosynthesis.
end case


case <OC:Bacteria>
SUBUNIT: Homodimer (By similarity).
end case

SUBCELLULAR LOCATION: Cytoplasm (Potential).
SIMILARITY: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
Cross-references
Pfam PF00202; Aminotran_3; 1;
TIGRFAMs TIGR00713; HemL; 1;
PROSITE PS00600; AA_TRANSFER_CLASS_3; 1;
Keywords
Cytoplasm, Porphyrin biosynthesis.

case <Property:PHOTOSYN>
Chlorophyll biosynthesis.
end case

Isomerase, Pyridoxal phosphate.
Gene Ontology
GO:0042286; Molecular function: glutamate-1-semialdehyde 2,1-aminomutase activity.

case <Property:PHOTOSYN>
GO:0015995; Biological process: chlorophyll biosynthetic process.
end case

GO:0006779; Biological process: porphyrin-containing compound biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
Features
From: GSA_ECOLI (P23893)
Key     From     To       Description   Condition   FTGroup
MOD_RES     265     265       N6-(pyridoxal phosphate)lysine (By similarity)   K  


Additional information

Size range: 412-466 amino acids
Related UniRules: None
Template: P23893 (GSA_ECOLI)
Scope: Bacteria
Archaea
Fusion: Nter: None; Cter: None
Duplicate: in ANOFW, BACA2, BACAA, BACAC, BACAH, BACAN, BACC0, BACC1, BACC2, BACC3, BACC4, BACC7, BACCN, BACCQ, BACCR, BACCZ, BACHD, BACHK, BACLD, BACP2, BACSK, BACSU, BACWK, BREBN, CENSY, CLOPH, EXIS2, EXISA, GEOKA, GEOTN, LISIN, LISMC, LISMF, LISMH, LISMO, LISW6, LYSSC, MACCJ, OCEIH, STAA1, STAA2, STAA3, STAA8, STAA9, STAAB, STAAC, STAAE, STAAM, STAAN, STAAR, STAAS, STAAT, STAAW, STACT, STAEQ, STAES, STAHJ, STAS1
Plasmid encoded: None
Comments: A third putative copy exists in BACHD. A second divergent copy exists in AERPE.

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UniProtKB rule member sequences