HAMAP

Accession	MF_00376
Dates	1-JUN-2001 (Created) 22-JUN-2011 (Last updated, Version 31)

Data class

Protein

Predictors

HAMAP; MF_00376; [distribution of match scores in UniProtKB];[seed alignment for MF_00376]

Names

Dephospho_CoA_kinase

Identifier

COAE

Protein name

RecName: Full=Dephospho-CoA kinase; EC=2.7.1.24; AltName: Full=Dephosphocoenzyme A kinase;

Gene name

coaE

FUNCTION: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity).

CATALYTIC ACTIVITY: ATP + 3'-dephospho-CoA = ADP + CoA.

PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the CoaE family.

SIMILARITY: Contains 1 DPCK (dephospho-CoA kinase) domain.

Pfam	PF01121; CoaE; 1;
TIGRFAMs	TIGR00152; TIGR00152; 1;
PROSITE	PS51219; DPCK; 1; trigger=PRU00564;

Cytoplasm, Transferase, Kinase, ATP-binding, Nucleotide-binding, Coenzyme A biosynthesis.

GO:0005524; Molecular function: ATP binding.
GO:0004140; Molecular function: dephospho-CoA kinase activity.
GO:0015937; Biological process: coenzyme A biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

From: COAE_ECOLI (P0A6I9)
Key		From		To		Description		Condition		FTGroup
NP_BIND		9		16		ATP (Potential)		[GA]-x(2)-[GASC]-x-G-K-[STDN]

Size range:	180-239 amino acids
Related UniRules:	None
Template:	P0A6I9 (COAE_ECOLI)
Scope:	Bacteria
Fusion:	Nter: None; Cter: <Unknown>
Duplicate:	None
Plasmid encoded:	None
Comments:	Unknown C-terminal domain in MYCLE, MYCPA and MYCTU. Natural frameshift reported in NEIMB.