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HAMAP rule MF_00376

General rule information [?]

Accession	MF_00376
Dates	1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 39)
Name	Dephospho_CoA_kinase
Scope(s)	Bacteria
Template(s)	P0A6I9 (COAE_ECOLI); P9WPA3 (COAE_MYCTU); Q56416 (COAE_THET8); [ Recover all ]
Triggered by	HAMAP; MF_00376 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	COAE
Protein name	RecName: Full=Dephospho-CoA kinase; EC=2.7.1.24; AltName: Full=Dephosphocoenzyme A kinase;
Gene name	Name=coaE;

Comments [?]

FUNCTION	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
CATALYTIC ACTIVITY	Reaction=3'-dephospho-CoA + ATP = ADP + CoA + H(+); Xref=Rhea:RHEA:18245, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57287, ChEBI:CHEBI:57328, ChEBI:CHEBI:456216; EC=2.7.1.24;
PATHWAY	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)- pantothenate: step 5/5.
SUBCELLULAR LOCATION	Cytoplasm.
case <Feature:PF04229>
DOMAIN	The C-terminal UPF0157 domain is involved in the proper folding of the full length enzyme.
end case
SIMILARITY	Belongs to the CoaE family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding

GO:0004140; Molecular function:dephospho-CoA kinase activity

GO:0015937; Biological process:coenzyme A biosynthetic process

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Features [?]

From: COAE_ECOLI (P0A6I9)

Key

From

Description

Tag

Condition

FTGroup

BINDING

/ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"

[GASC]-x-G-K-[STDN]-x

Additional information [?]

Size range	150-300 amino acids
Related rules	None
Fusion	Nter: None Cter: <UPF0157>
Comments	The UPF0157 (GrpB) C-terminal domain present in some species is probably involved in the folding of the protein. Natural frameshift reported in NEIMB.