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HAMAP rule MF_00384

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General rule information [?]

Accession MF_00384
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 33)
Name Homoser_kinase
Scope(s) Bacteria
Archaea
Template(s) P00547 (KHSE_ECOLI); Q6M0H5 (KHSE_METMP); Q58504 (KHSE_METJA); [ Recover all ]
Triggered by HAMAP; MF_00384 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier KHSE
Protein name RecName: Full=Homoserine kinase;
                 Short=HK;
                 Short=HSK;
                 EC=2.7.1.39;
Gene name Name=thrB;

Comments [?]

FUNCTIONCatalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
CATALYTIC ACTIVITY Reaction=ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine; Xref=Rhea:RHEA:13985, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57476, ChEBI:CHEBI:57590, ChEBI:CHEBI:456216; EC=2.7.1.39;
PATHWAYAmino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the GHMP kinase family. Homoserine kinase subfamily.

Keywords [?]


Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0004413; Molecular function:homoserine kinase activity
GO:0009088; Biological process:threonine biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF08544; GHMP_kinases_C; 1;
Pfam PF00288; GHMP_kinases_N; 1;
PIRSF PIRSF000676; Homoser_kin; 1;
PRINTS PR00958; HOMSERKINASE; 1;
NCBIfam TIGR00191; ThrB; 1;
PROSITE PS00627; GHMP_KINASES_ATP; 1;

Features [?]

From: KHSE_ECOLI (P00547)
Key From To Description Tag Condition FTGroup
BINDING 91 101 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
[APKR]-x(3)-G-[LFM]-G-[GS]-S-[GSA]-[STAC]

Additional information [?]

Size range 281-324 amino acids
Related rules MF_00217
Fusion Nter: None Cter: None
Comments Some other species have a non-classical-type thrB



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