HAMAP rule MF_00384
General rule information
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| Accession | MF_00384 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 33) |
| Name | Homoser_kinase |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P00547 (KHSE_ECOLI); Q6M0H5 (KHSE_METMP); Q58504 (KHSE_METJA); [ Recover all ] |
| Triggered by |
HAMAP; MF_00384 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | KHSE |
| Protein name | RecName: Full=Homoserine kinase; Short=HK; Short=HSK; EC=2.7.1.39; |
| Gene name | Name=thrB; |
Comments
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| FUNCTION | Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate. |
| CATALYTIC ACTIVITY | Reaction=ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine; Xref=Rhea:RHEA:13985, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57476, ChEBI:CHEBI:57590, ChEBI:CHEBI:456216; EC=2.7.1.39; |
| PATHWAY | Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the GHMP kinase family. Homoserine kinase subfamily. |
Keywords
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| Cytoplasm |
| Amino-acid biosynthesis |
| Threonine biosynthesis |
| Transferase |
| Kinase |
| ATP-binding |
| Nucleotide-binding |
Gene Ontology
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| GO:0005524; Molecular function:ATP binding |
| GO:0004413; Molecular function:homoserine kinase activity |
| GO:0009088; Biological process:threonine biosynthetic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF08544; GHMP_kinases_C; 1; |
| Pfam | PF00288; GHMP_kinases_N; 1; |
| PIRSF | PIRSF000676; Homoser_kin; 1; |
| PRINTS | PR00958; HOMSERKINASE; 1; |
| NCBIfam | TIGR00191; ThrB; 1; |
| PROSITE | PS00627; GHMP_KINASES_ATP; 1; |
Features
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| From: KHSE_ECOLI (P00547) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 91 | 101 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[APKR]-x(3)-G-[LFM]-G-[GS]-S-[GSA]-[STAC] | ||||||||
Additional information
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| Size range | 281-324 amino acids |
| Related rules |
MF_00217 |
| Fusion | Nter: None Cter: None |
| Comments | Some other species have a non-classical-type thrB |