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HAMAP rule MF_00387

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General rule information [?]

Accession MF_00387
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 36)
Name LpxA
Scope(s) Bacteria
Plastid
Template(s) P0A722 (LPXA_ECOLI); P32199 (LPXA_RICRI); [ Recover all ]
Triggered by HAMAP; MF_00387 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier LPXA
Protein name RecName: Full=Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase;
                 Short=UDP-N-acetylglucosamine acyltransferase;
                 EC=2.3.1.129;
Gene name Name=lpxA;

Comments [?]

case not <OG:Chloroplast>
FUNCTIONInvolved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
end case
case <OG:Chloroplast>
FUNCTIONInvolved in the biosynthesis of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell. The target for the lipopolysaccharides produced in the chloroplast could either be the cell envelope of the eukaryote or the plastid membrane.
end case
CATALYTIC ACTIVITY Reaction=a (3R)-hydroxyacyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine = a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + holo- [ACP]; Xref=Rhea:RHEA:67812, Rhea:RHEA-COMP:9685, Rhea:RHEA- COMP:9945, ChEBI:CHEBI:57705, ChEBI:CHEBI:64479, ChEBI:CHEBI:78827, ChEBI:CHEBI:173225; EC=2.3.1.129;
PATHWAYGlycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N- acetyl-alpha-D-glucosamine: step 1/6.
SUBUNITHomotrimer.
case <OG:Chloroplast>
SUBCELLULAR LOCATIONPlastid, chloroplast.
else
SUBCELLULAR LOCATIONCytoplasm.
end case
SIMILARITYBelongs to the transferase hexapeptide repeat family. LpxA subfamily.

Keywords [?]


Gene Ontology [?]

GO:0008780; Molecular function:acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity
GO:0009245; Biological process:lipid A biosynthetic process
case <OG:Chloroplast>
GO:0009507; Cellular component:chloroplast
else; https://www.ebi.ac.uk/QuickGO/term/else
GO:0005737; Cellular component:cytoplasm
end case

Cross-references [?]

Pfam PF00132; Hexapep; 5-8;
PIRSF PIRSF000456; UDP-GlcNAc_acltr; 1;
NCBIfam TIGR01852; Lipid_A_lpxA; 1;
PROSITE PS00101; HEXAPEP_TRANSFERASES; 1;

Features [?]


Additional information [?]

Size range 257-283 amino acids
Related rules MF_00523
Fusion Nter: None Cter: None



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