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HAMAP annotation rule: MF_00387
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General rule information

Accession MF_00387
Dates 1-JUN-2001 (Created)
9-JUN-2011 (Last updated, Version 29)
Data class Protein
Predictors HAMAP; MF_00387; [distribution of match scores in UniProtKB];[seed alignment for MF_00387]
Names LpxA


Propagated annotation

Identifier, protein and gene names
Identifier LPXA
Protein name
RecName: Full=Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase;
Short=UDP-N-acetylglucosamine acyltransferase;
EC=2.3.1.129;
Gene name lpxA
Comments

case not <OG:Chloroplast>
FUNCTION: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity).
end case


case <OG:Chloroplast>
FUNCTION: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell. The target for the lipopolysaccharides produced in the chloroplast could either be the cell envelope of the eukaryote or the plastid membrane (Potential).
end case

CATALYTIC ACTIVITY: (R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetylglucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine.
PATHWAY: Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6.
SUBUNIT: Homotrimer (By similarity).

case <OG:Chloroplast>
SUBCELLULAR LOCATION: Plastid, chloroplast.

else
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
end case

SIMILARITY: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
Cross-references
Pfam PF00132; Hexapep; 5-8;
PIRSF PIRSF000456; UDP-GlcNAc_acltr; 1;
TIGRFAMs TIGR01852; Lipid_A_lpxA; 1;
PROSITE PS00101; HEXAPEP_TRANSFERASES; 1;
Keywords

case not <OG:Chloroplast>
Cytoplasm.
end case

Transferase, Acyltransferase, Lipid A biosynthesis, Lipid synthesis, Repeat.
Gene Ontology
GO:0008780; Molecular function: acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity.
GO:0009245; Biological process: lipid A biosynthetic process.

case <OG:Chloroplast>
GO:0009507; Cellular component: chloroplast.

else
GO:0005737; Cellular component: cytoplasm.
end case



Additional information

Size range: 257-283 amino acids
Related UniRules: MF_00523 (LPXD)
Template: P0A722 (LPXA_ECOLI); P32199 (LPXA_RICRI): [Recover all]
Scope: Bacteria
Plastid
Fusion: Nter: None; Cter: None
Duplicate: None
Plasmid encoded: None

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UniProtKB rule member sequences