HAMAP

Accession	MF_00388
Dates	1-JUN-2001 (Created) 25-NOV-2011 (Last updated, Version 23)

Data class

Protein

Predictors

HAMAP; MF_00388; [distribution of match scores in UniProtKB];[seed alignment for MF_00388]

Names

LpxC

Identifier

LPXC

Protein name

RecName: Full=UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; EC=3.5.1.-; AltName: Full=UDP-3-O-acyl-GlcNAc deacetylase;

Gene name

lpxC

FUNCTION: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity).

FUNCTION: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell. The target for the lipopolysaccharides produced in the chloroplast could either be the cell envelope of the eukaryote or the plastid membrane (Potential).

CATALYTIC ACTIVITY: UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + H(2)O = UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine + acetate.

PATHWAY: Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6.

SUBCELLULAR LOCATION: Plastid, chloroplast.

SIMILARITY: Belongs to the LpxC family.

TIGRFAMs

TIGR00325; LpxC; 1;

Hydrolase, Lipid A biosynthesis, Lipid synthesis.

GO:0008759; Molecular function: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity.
GO:0009245; Biological process: lipid A biosynthetic process.

GO:0009507; Cellular component: chloroplast.

Size range:	276-307 amino acids
Related UniRules:	None
Template:	P0A725 (LPXC_ECOLI)
Scope:	Bacteria Plastid
Fusion:	Nter: None; Cter: MF_00406 (fabZ)
Duplicate:	None
Plasmid encoded:	None