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HAMAP rule MF_00388

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General rule information [?]

Accession MF_00388
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 32)
Name LpxC
Scope(s) Bacteria
Plastid
Template(s) P0A725 (LPXC_ECOLI); O67648 (LPXC_AQUAE); P47205 (LPXC_PSEAE); [ Recover all ]
Triggered by HAMAP; MF_00388 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier LPXC
Protein name RecName: Full=UDP-3-O-acyl-N-acetylglucosamine deacetylase;
                 Short=UDP-3-O-acyl-GlcNAc deacetylase;
                 EC=3.5.1.108;
AltName: Full=UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase;
Gene name Name=lpxC;

Comments [?]

case <OC:Bacteria>
FUNCTIONCatalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
end case
case <OG:Chloroplast>
FUNCTIONCatalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell. The target for the lipopolysaccharides produced in the chloroplast could either be the cell envelope of the eukaryote or the plastid membrane.
end case
CATALYTIC ACTIVITY Reaction=a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate; Xref=Rhea:RHEA:67816, ChEBI:CHEBI:15377, ChEBI:CHEBI:30089, ChEBI:CHEBI:137740, ChEBI:CHEBI:173225; EC=3.5.1.108;
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
PATHWAYGlycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N- acetyl-alpha-D-glucosamine: step 2/6.
case <OG:Chloroplast>
SUBCELLULAR LOCATIONPlastid, chloroplast.
end case
SIMILARITYBelongs to the LpxC family.

Keywords [?]


Gene Ontology [?]

GO:0008759; Molecular function:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GO:0009245; Biological process:lipid A biosynthetic process
case <OG:Chloroplast>
GO:0009507; Cellular component:chloroplast
end case

Cross-references [?]

Pfam PF03331; LpxC; 1;
NCBIfam TIGR00325; lpxC; 1;

Features [?]

From: LPXC_ECOLI (P0A725)
Key From To Description Tag Condition FTGroup
ACT_SITE 265 265 /note="Proton donor" H
BINDING 79 79 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
H
BINDING 238 238 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
H
BINDING 242 242 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
D

Additional information [?]

Size range 250-350 amino acids
Related rules None
Fusion Nter: None Cter: MF_00406 (fabZ)



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