HAMAP rule MF_00392
General rule information
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Accession | MF_00392 |
Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 28) |
Name | LpxB |
Scope(s) |
Bacteria |
Template(s) | P10441 (LPXB_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_00392 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | LPXB |
Protein name | RecName: Full=Lipid-A-disaccharide synthase; EC=2.4.1.182; |
Gene name | Name=lpxB; |
Comments
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FUNCTION | Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. |
case <OC:Enterobacterales> | |
CATALYTIC ACTIVITY | Reaction=2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D- glucosamine = H(+) + lipid A disaccharide (E. coli) + UDP; Xref=Rhea:RHEA:22668, ChEBI:CHEBI:15378, ChEBI:CHEBI:57957, ChEBI:CHEBI:58223, ChEBI:CHEBI:58466, ChEBI:CHEBI:78847; |
end case | |
CATALYTIC ACTIVITY | Reaction=a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D- glucosamine = a lipid A disaccharide + H(+) + UDP; Xref=Rhea:RHEA:67828, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:137748, ChEBI:CHEBI:176338, ChEBI:CHEBI:176343; EC=2.4.1.182; |
case <OC:Enterobacterales> | |
PATHWAY | Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N- acetyl-alpha-D-glucosamine: step 5/6. |
else | |
PATHWAY | Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. |
end case | |
SIMILARITY | Belongs to the LpxB family. |
Keywords
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Gene Ontology
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GO:0008915; Molecular function:lipid-A-disaccharide synthase activity |
GO:0009245; Biological process:lipid A biosynthetic process |
Cross-references
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Features
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Additional information
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Size range | 356-439 amino acids |
Related rules |
None |
Fusion | Nter: <Unknown> Cter: None |
Comments | Unknown N-terminal domain in Chlamydiaceae. Possible wrong start in XANAC. |