HAMAP

Accession	MF_00392
Dates	1-JUN-2001 (Created) 9-DEC-2011 (Last updated, Version 20)

Data class

Protein

Predictors

HAMAP; MF_00392; [distribution of match scores in UniProtKB];[seed alignment for MF_00392]

Names

LpxB

Identifier

LPXB

Protein name

RecName: Full=Lipid-A-disaccharide synthase; EC=2.4.1.182;

Gene name

lpxB

FUNCTION: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity).

CATALYTIC ACTIVITY: UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.

PATHWAY: Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6.

SIMILARITY: Belongs to the LpxB family.

Pfam	PF02684; LpxB; 1;
TIGRFAMs	TIGR00215; LpxB; 1;

Transferase, Glycosyltransferase, Lipid A biosynthesis, Lipid synthesis.

GO:0008915; Molecular function: lipid-A-disaccharide synthase activity.
GO:0009245; Biological process: lipid A biosynthetic process.

Size range:	356-439 amino acids
Related UniRules:	None
Template:	P10441 (LPXB_ECOLI)
Scope:	Bacteria
Fusion:	Nter: <Unknown>; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	Unknown N-terminal domain in Chlamydiaceae. Possible wrong start in XANAC.