HAMAP rule MF_00394
General rule information
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| Accession | MF_00394 |
| Dates | 1-JUN-2001 (Created)
19-NOV-2022 (Last updated, Version 37) |
| Name | NAD_Glyc3P_dehydrog |
| Scope(s) |
Bacteria Archaea |
| Template(s) | O29390 (GPDA_ARCFU); [ Recover all ] |
| Triggered by |
HAMAP; MF_00394 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | GPDA |
| Protein name | RecName: Full=Glycerol-3-phosphate dehydrogenase [NAD(P)+]; EC=1.1.1.94; AltName: Full=NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; |
| Gene name | Name=gpsA; |
Comments
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| CATALYTIC ACTIVITY | Reaction=NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH; Xref=Rhea:RHEA:11092, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57597, ChEBI:CHEBI:57642, ChEBI:CHEBI:57945; EC=1.1.1.94; |
| CATALYTIC ACTIVITY | Reaction=NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH; Xref=Rhea:RHEA:11096, ChEBI:CHEBI:15378, ChEBI:CHEBI:57597, ChEBI:CHEBI:57642, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.94; |
| SUBCELLULAR LOCATION | Cytoplasm. |
| PATHWAY | Membrane lipid metabolism; glycerophospholipid metabolism. |
| SIMILARITY | Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. |
Keywords
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| Cytoplasm |
| Lipid biosynthesis |
| Lipid metabolism |
| Phospholipid biosynthesis |
| Phospholipid metabolism |
| NAD |
| Oxidoreductase |
Gene Ontology
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| GO:0047952; Molecular function:glycerol-3-phosphate dehydrogenase [NAD(P)+] activity |
| GO:0046167; Biological process:glycerol-3-phosphate biosynthetic process |
| GO:0008654; Biological process:phospholipid biosynthetic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF07479; NAD_Gly3P_dh_C; 1; |
| Pfam | PF01210; NAD_Gly3P_dh_N; 1; |
| PIRSF | PIRSF000114; Glycerol-3-P_dh; 1; |
| PRINTS | PR00077; GPDHDRGNASE; 1; |
| PROSITE | PS00957; NAD_G3PDH; 1; |
Features
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| From: GPDA_ECOLI (P0A6S7) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 12 | 17 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
|||||||||
| BINDING | 259 | 260 | /ligand="substrate" | R-N | ||||||||
| ACT_SITE | 195 | 195 | /note="Proton acceptor" | K | ||||||||
| BINDING | 110 | 110 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
K | ||||||||
| BINDING | 110 | 110 | /ligand="substrate" | K | ||||||||
| BINDING | 143 | 143 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
[AS] | ||||||||
| BINDING | 259 | 259 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
R | ||||||||
| BINDING | 285 | 285 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
E | ||||||||
Additional information
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| Size range | 297-369 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |