HAMAP

Accession	MF_00399
Dates	1-JUN-2001 (Created) 2-DEC-2010 (Last updated, Version 35)

Data class

Protein

Predictors

HAMAP; MF_00399; [distribution of match scores in UniProtKB];[seed alignment for MF_00399]

Names

DbsD

Identifier

DSBD

Protein name

RecName: Full=Thiol:disulfide interchange protein DsbD; EC=1.8.1.8; AltName: Full=Protein-disulfide reductase; Short=Disulfide reductase; Flags: Precursor;

Gene name

dsbD

FUNCTION: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity).

CATALYTIC ACTIVITY: Protein dithiol + NAD(P)(+) = protein disulfide + NAD(P)H.

SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein (By similarity).

SIMILARITY: Belongs to the thioredoxin family. DsbD subfamily.

SIMILARITY: Contains 1 thioredoxin domain.

Pfam	PF02683; DsbD; 1; PF00085; Thioredoxin; 1;
PRINTS	PR00421; THIOREDOXIN; 1;
PROSITE	PS00194; THIOREDOXIN_1; 1; PS51352; THIOREDOXIN_2; 1; trigger=PRU00691;
General	Signal; -; 1; trigger=Yes; Transmembrane; -; 8; trigger=Yes;

Cell inner membrane, Cell membrane, Cytochrome c-type biogenesis, Disulfide bond, Electron transport, Membrane, NAD, Oxidoreductase, Redox-active center, Signal, Transmembrane, Transport, Transmembrane helix.

GO:0009055; Molecular function: electron carrier activity.
GO:0047134; Molecular function: protein-disulfide reductase activity.
GO:0017004; Biological process: cytochrome complex assembly.
GO:0055114; Biological process: oxidation-reduction process.
GO:0005886; Cellular component: plasma membrane.

From: DSBD_ECOLI (P36655)
Key		From		To		Description		Condition		FTGroup
DISULFID		122		128		Redox-active (By similarity)		C-x(4,5)-C
DISULFID		182		304		Redox-active (By similarity)		C-x*-C
DISULFID		480		483		Redox-active (By similarity)		C-x(2)-C

Size range:	565-608 amino acids
Related UniRules:	None
Template:	P36655 (DSBD_ECOLI)
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	in PSEAE
Plasmid encoded:	None
Comments:	Possible wrong start in RALSO