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| HAMAP annotation rule MF_00407 |
| Accession | MF_00407 |
| Dates | 1-JUN-2001 (Created) 9-JUN-2011 (Last updated, Version 21) |
| Name | DNA_ligase |
| Scope | Bacteria Archaea |
| Triggered by |
| Identifier |
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case <OC:Archaea>
| Protein name |
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else case <OC:Bacteria>
| Protein name |
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end case
| Gene name |
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| FUNCTION | DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity). |
| CATALYTIC ACTIVITY | ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). |
| COFACTOR | Divalent metal cations (By similarity). |
| SIMILARITY | Belongs to the ATP-dependent DNA ligase family. |
DNA damage
DNA repair
DNA replication
DNA recombination
Cell cycle
Cell division
Ligase
ATP-binding
Metal-binding
Nucleotide-binding
DNA repair
DNA replication
DNA recombination
Cell cycle
Cell division
Ligase
ATP-binding
Metal-binding
Nucleotide-binding
GO:0005524; Molecular function: ATP binding.
GO:0003910; Molecular function: DNA ligase (ATP) activity.
GO:0006310; Biological process: DNA recombination.
GO:0006281; Biological process: DNA repair.
GO:0006260; Biological process: DNA replication.
GO:0003910; Molecular function: DNA ligase (ATP) activity.
GO:0006310; Biological process: DNA recombination.
GO:0006281; Biological process: DNA repair.
GO:0006260; Biological process: DNA replication.
| Pfam | PF04679; DNA_ligase_A_C; 1; |
| PF01068; DNA_ligase_A_M; 1; | |
| PF04675; DNA_ligase_A_N; 1; | |
| TIGRFAMs | TIGR00574; Dnl1; 1; |
| PROSITE | PS00697; DNA_LIGASE_A1; 1; |
| PS00333; DNA_LIGASE_A2; 1; | |
| PS50160; DNA_LIGASE_A3; 1; |
| From: DNLI_PYRFU (P56709) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 249 | 249 | N6-AMP-lysine intermediate (By similarity) | K | ||||||||
| BINDING | 247 | 247 | ATP (By similarity) | [DE] | ||||||||
| BINDING | 254 | 254 | ATP (By similarity) | R | ||||||||
| BINDING | 269 | 269 | ATP (By similarity) | R | ||||||||
| BINDING | 299 | 299 | ATP (By similarity) | E | ||||||||
| BINDING | 339 | 339 | ATP (By similarity) | F | ||||||||
| BINDING | 414 | 414 | ATP (By similarity) | R | ||||||||
| BINDING | 420 | 420 | ATP (By similarity) | K | ||||||||
| Size range: | 503-618 amino acids |
| Related Rules: | None |
| Templates: | P56709 (DNLI_PYRFU); Q9HHC4 (DNLI_PYRKO); Q980T8 (DNLI_SULSO): [Recover all] |
| Fusion: | Nter: <Unknown>; Cter: None |
| Comments: | Shorter N-terminus in the first copy of lig in METBF. |