 |
|
| HAMAP annotation rule: MF_00407 |
| Accession |
MF_00407 |
| Dates |
1-JUN-2001 (Created) 9-JUN-2011 (Last updated, Version 21) |
case <OC:Archaea>
| Protein name |
| RecName: |
Full=DNA ligase; EC=6.5.1.1; |
| AltName: |
Full=Polydeoxyribonucleotide synthase [ATP]; |
|
else case <OC:Bacteria>
| Protein name |
| RecName: |
Full=Probable DNA ligase; EC=6.5.1.1; |
| AltName: |
Full=Polydeoxyribonucleotide synthase [ATP]; |
|
end case
FUNCTION: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity).
CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).
COFACTOR: Divalent metal cations (By similarity).
SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
| From: DNLI_PYRFU (P56709) |
| Key |
|
From |
|
To |
|
Description |
|
Condition |
|
FTGroup |
| ACT_SITE |
|
249 |
|
249 |
|
N6-AMP-lysine intermediate (By similarity) |
|
K |
|
|
| BINDING |
|
247 |
|
247 |
|
ATP (By similarity) |
|
[DE] |
|
|
| BINDING |
|
254 |
|
254 |
|
ATP (By similarity) |
|
R |
|
|
| BINDING |
|
269 |
|
269 |
|
ATP (By similarity) |
|
R |
|
|
| BINDING |
|
299 |
|
299 |
|
ATP (By similarity) |
|
E |
|
|
| BINDING |
|
339 |
|
339 |
|
ATP (By similarity) |
|
F |
|
|
| BINDING |
|
414 |
|
414 |
|
ATP (By similarity) |
|
R |
|
|
| BINDING |
|
420 |
|
420 |
|
ATP (By similarity) |
|
K |
|
|
| Size range: |
503-618 amino acids |
| Related UniRules: |
None |
| Template: |
P56709 (DNLI_PYRFU); Q9HHC4 (DNLI_PYRKO); Q980T8 (DNLI_SULSO): [Recover all] |
| Scope: |
Bacteria
Archaea |
| Fusion: |
Nter: <Unknown>; Cter: None |
| Duplicate: |
None |
| Plasmid encoded: |
None |
| Comments: |
Shorter N-terminus in the first copy of lig in METBF. |
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