Annotation rule MF_00407
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General rule information [?]

Accession MF_00407
Dates 1-JUN-2001 (Created)
9-JUN-2011 (Last updated, Version 21)
Name DNA_ligase
Scope Bacteria
Archaea

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
DNLI
case <OC:Archaea>
Protein name
RecName: Full=DNA ligase;
EC=6.5.1.1;
AltName: Full=Polydeoxyribonucleotide synthase [ATP];
else case <OC:Bacteria>
Protein name
RecName: Full=Probable DNA ligase;
EC=6.5.1.1;
AltName: Full=Polydeoxyribonucleotide synthase [ATP];
end case
Gene name
lig

Comments [?]

Function DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity).
Catalytic activity ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).
Cofactor Divalent metal cations (By similarity).
Similarity Belongs to the ATP-dependent DNA ligase family.

Keywords [?]


Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0003910; Molecular function: DNA ligase (ATP) activity.
GO:0006310; Biological process: DNA recombination.
GO:0006281; Biological process: DNA repair.
GO:0006260; Biological process: DNA replication.

Cross-references [?]

Pfam PF04679; DNA_ligase_A_C; 1;
PF01068; DNA_ligase_A_M; 1;
PF04675; DNA_ligase_A_N; 1;
TIGRFAMs TIGR00574; Dnl1; 1;
PROSITE PS00697; DNA_LIGASE_A1; 1;
PS00333; DNA_LIGASE_A2; 1;
PS50160; DNA_LIGASE_A3; 1;

Features [?]

From: DNLI_PYRFU (P56709)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     249     249       N6-AMP-lysine intermediate (By similarity)     K  
BINDING     247     247       ATP (By similarity)     [DE]  
BINDING     254     254       ATP (By similarity)     R  
BINDING     269     269       ATP (By similarity)     R  
BINDING     299     299       ATP (By similarity)     E  
BINDING     339     339       ATP (By similarity)     F  
BINDING     414     414       ATP (By similarity)     R  
BINDING     420     420       ATP (By similarity)     K  

Additional information [?]

Size range 503-618 amino acids
Related rules None
Templates P56709 (DNLI_PYRFU); Q9HHC4 (DNLI_THEKO); Q980T8 (DNLI_SULSO): [Recover all]
Fusion Nter: <Unknown>; Cter: None
Comments Shorter N-terminus in the first copy of lig in METBF.