HAMAP

Accession	MF_00407
Dates	1-JUN-2001 (Created) 9-JUN-2011 (Last updated, Version 21)

Data class

Protein

Predictors

HAMAP; MF_00407; [distribution of match scores in UniProtKB];[seed alignment for MF_00407]

Names

DNA_ligase

Identifier

DNLI

Protein name

RecName: Full=DNA ligase; EC=6.5.1.1; AltName: Full=Polydeoxyribonucleotide synthase [ATP];

Protein name

RecName: Full=Probable DNA ligase; EC=6.5.1.1; AltName: Full=Polydeoxyribonucleotide synthase [ATP];

Gene name

lig

FUNCTION: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity).

CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

COFACTOR: Divalent metal cations (By similarity).

SIMILARITY: Belongs to the ATP-dependent DNA ligase family.

Pfam	PF04679; DNA_ligase_A_C; 1; PF01068; DNA_ligase_A_M; 1; PF04675; DNA_ligase_A_N; 1;
TIGRFAMs	TIGR00574; Dnl1; 1;
PROSITE	PS00697; DNA_LIGASE_A1; 1; PS00333; DNA_LIGASE_A2; 1; PS50160; DNA_LIGASE_A3; 1;

DNA damage, DNA repair, DNA replication, DNA recombination, Cell cycle, Cell division, Ligase, ATP-binding, Metal-binding, Nucleotide-binding.

GO:0005524; Molecular function: ATP binding.
GO:0003910; Molecular function: DNA ligase (ATP) activity.
GO:0006310; Biological process: DNA recombination.
GO:0006281; Biological process: DNA repair.
GO:0006260; Biological process: DNA replication.

From: DNLI_PYRFU (P56709)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		249		249		N6-AMP-lysine intermediate (By similarity)		K
BINDING		247		247		ATP (By similarity)		[DE]
BINDING		254		254		ATP (By similarity)		R
BINDING		269		269		ATP (By similarity)		R
BINDING		299		299		ATP (By similarity)		E
BINDING		339		339		ATP (By similarity)		F
BINDING		414		414		ATP (By similarity)		R
BINDING		420		420		ATP (By similarity)		K

Size range:	503-618 amino acids
Related UniRules:	None
Template:	P56709 (DNLI_PYRFU); Q9HHC4 (DNLI_PYRKO); Q980T8 (DNLI_SULSO): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: <Unknown>; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	Shorter N-terminus in the first copy of lig in METBF.