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| HAMAP annotation rule MF_00409 |
| Accession | MF_00409 |
| Dates | 1-JUN-2001 (Created) 13-JUL-2012 (Last updated, Version 23) |
| Name | LpxK |
| Scope | Bacteria |
| Triggered by |
| Identifier |
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| Protein name |
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| Gene name |
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| FUNCTION | Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity). |
| CATALYTIC ACTIVITY | ATP + (2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl)-(1->6)-(2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl phosphate) = ADP + (2-N,3-O-bis(3-hydroxytetradecanoyl)-4-O-phosphono-beta-D-glucosaminyl)-(1->6)-(2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl phosphate). |
| PATHWAY | Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine; step 6/6. |
| SIMILARITY | Belongs to the LpxK family. |
ATP-binding
Kinase
Lipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
Nucleotide-binding
Transferase
Kinase
Lipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
Nucleotide-binding
Transferase
GO:0005524; Molecular function: ATP binding.
GO:0009029; Molecular function: tetraacyldisaccharide 4'-kinase activity.
GO:0009245; Biological process: lipid A biosynthetic process.
GO:0009029; Molecular function: tetraacyldisaccharide 4'-kinase activity.
GO:0009245; Biological process: lipid A biosynthetic process.
| From: LPXK_ECOLI (P27300) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| NP_BIND | 55 | 62 | ATP (Potential) | x(2)-G-G-x-G-K-T | ||||||||
| Size range: | 305-385 amino acids |
| Related Rules: | None |
| Template: | P27300 (LPXK_ECOLI) |
| Fusion: | Nter: None; Cter: MF_01187 (Ynnn) |