HAMAP rule MF_00409
General rule information
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| Accession | MF_00409 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 32) |
| Name | LpxK |
| Scope(s) |
Bacteria |
| Template(s) | P27300 (LPXK_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00409 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | LPXK |
| Protein name | RecName: Full=Tetraacyldisaccharide 4'-kinase; EC=2.7.1.130; AltName: Full=Lipid A 4'-kinase; |
| Gene name | Name=lpxK; |
Comments
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| FUNCTION | Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). |
| CATALYTIC ACTIVITY | Reaction=a lipid A disaccharide + ATP = a lipid IVA + ADP + H(+); Xref=Rhea:RHEA:67840, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:176343, ChEBI:CHEBI:176425, ChEBI:CHEBI:456216; EC=2.7.1.130; |
| PATHWAY | Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N- acetyl-alpha-D-glucosamine: step 6/6. |
| SIMILARITY | Belongs to the LpxK family. |
Keywords
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| ATP-binding |
| Kinase |
| Lipid A biosynthesis |
| Lipid biosynthesis |
| Lipid metabolism |
| Nucleotide-binding |
| Transferase |
Gene Ontology
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| GO:0005524; Molecular function:ATP binding |
| GO:0009029; Molecular function:tetraacyldisaccharide 4'-kinase activity |
| GO:0009245; Biological process:lipid A biosynthetic process |
Cross-references
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Features
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| From: LPXK_ECOLI (P27300) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 55 | 62 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
x(2)-G-G-x-G-K-T | ||||||||
Additional information
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| Size range | 305-385 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: MF_01187 (Ynnn) |