HAMAP

Accession	MF_00420
Dates	26-JUN-2001 (Created) 25-NOV-2011 (Last updated, Version 36)

Data class

Protein

Predictors

HAMAP; MF_00420; [distribution of match scores in UniProtKB];[seed alignment for MF_00420]

Names

PurL_2

Identifier

PURL

Protein name

RecName: Full=Phosphoribosylformylglycinamidine synthase 2; EC=6.3.5.3; AltName: Full=Phosphoribosylformylglycinamidine synthase II; Short=FGAM synthase II;

Gene name

purL

CATALYTIC ACTIVITY: ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H(2)O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate.

PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.

SUBUNIT: Heterodimer of two subunits, PurQ and PurL (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the FGAMS family.

Pfam	PF00586; AIRS; 1; PF02769; AIRS_C; 1;
TIGRFAMs	TIGR01736; FGAM_synth_II; 1;

Cytoplasm, Purine biosynthesis, Ligase, ATP-binding, Nucleotide-binding.

GO:0005524; Molecular function: ATP binding.
GO:0004642; Molecular function: phosphoribosylformylglycinamidine synthase activity.
GO:0006164; Biological process: purine nucleotide biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

From: PURL_BACSU (P12042)
Key		From		To		Description		Condition		FTGroup
NP_BIND		111		122		ATP (Potential)		G-[AS]-[GATS]-T-G-x-G-G-[IV]-x-R-D

Size range:	603-824 amino acids
Related UniRules:	MF_00419 (PUR4)
Template:	P12042 (PURL_BACSU); Q9ZB06 (PURL_LACLC): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	Possible wrong starts in many sequences. Possible C-terminal error in THEMA.