HAMAP

Accession	MF_00421
Dates	26-JUN-2001 (Created) 25-NOV-2011 (Last updated, Version 34)

Data class

Protein

Predictors

HAMAP; MF_00421; [distribution of match scores in UniProtKB];[seed alignment for MF_00421]

Names

PurQ

Identifier

PURQ

Protein name

RecName: Full=Phosphoribosylformylglycinamidine synthase 1; EC=6.3.5.3; AltName: Full=Phosphoribosylformylglycinamidine synthase I; Short=FGAM synthase I;

Gene name

purQ

CATALYTIC ACTIVITY: ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H(2)O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate.

PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.

SUBUNIT: Heterodimer of two subunits, PurQ and PurL (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Contains 1 glutamine amidotransferase type-1 domain.

PROSITE

PS51273; GATASE_TYPE_1; 1; trigger=PRU00605;

ATP-binding, Cytoplasm, Glutamine amidotransferase, Ligase, Nucleotide-binding, Purine biosynthesis.

GO:0004642; Molecular function: phosphoribosylformylglycinamidine synthase activity.
GO:0006164; Biological process: purine nucleotide biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

From: PURQ_BACSU (P12041)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		86		86		Nucleophile (By similarity)		C
ACT_SITE		194		194		By similarity		H
ACT_SITE		196		196		By similarity		E

Size range:	212-272 amino acids
Related UniRules:	MF_00419 (PUR4)
Template:	P35851 (PURQ_LACCA)
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None