Home Proteomes Families Hamap-Scan Documents Downloads Links
HAMAP annotation rule: MF_00426
Send feedback new

General rule information

Accession MF_00426
Dates 16-JUL-2001 (Created)
9-JUN-2011 (Last updated, Version 34)
Data class Protein
Predictors HAMAP; MF_00426; [distribution of match scores in UniProtKB];[seed alignment for MF_00426]
Names NqrB


Propagated annotation

Identifier, protein and gene names
Identifier NQRB
Protein name
RecName: Full=Na(+)-translocating NADH-quinone reductase subunit B;
Short=Na(+)-NQR subunit B;
Short=Na(+)-translocating NQR subunit B;
EC=1.6.5.-;
AltName: Full=NQR complex subunit B;
AltName: Full=NQR-1 subunit B;
Gene name nqrB
Comments
FUNCTION: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to nqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity).
CATALYTIC ACTIVITY: NADH + ubiquinone + Na(+)(In) = NAD(+) + ubiquinol + Na(+)(Out).
COFACTOR: FMN (By similarity).
SUBUNIT: Composed of six subunits; nqrA, nqrB, nqrC, nqrD, nqrE and nqrF (By similarity).

case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (Potential).

else case <Property:Membrane=2>
SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein (Potential).
end case

SIMILARITY: Belongs to the nqrB/rnfD family.
Cross-references
Pfam PF03116; NQR2_RnfD_RnfE; 1;
PIRSF PIRSF016055; NADH-UbQ_OxRdtase_B_su; 1;
TIGRFAMs TIGR01937; NqrB; 1;
General Transmembrane; -; 8-10; trigger=Yes;
Keywords
Oxidoreductase, NAD, Ubiquinone, Transport, Ion transport, Sodium, Sodium transport, Flavoprotein, FMN, Cell membrane, Membrane, Transmembrane.

case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane.
end case


case <FT:1>
Phosphoprotein.
end case

Transmembrane helix.
Gene Ontology
GO:0016655; Molecular function: oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor.
GO:0006814; Biological process: sodium ion transport.
GO:0005886; Cellular component: plasma membrane.
Features
From: NQRB_VIBAL (Q56587)
Key     From     To       Description   Condition   FTGroup
MOD_RES     236     236       FMN phosphoryl threonine (By similarity)   T  


Additional information

Size range: 403-503 amino acids
Related UniRules: MF_00462 (RNFD)
Template: Q56587 (NQRB_VIBAL)
Scope: Bacteria
Fusion: Nter: None; Cter: None
Duplicate: None
Plasmid encoded: None

View rule in raw text format (no links)



UniProtKB rule member sequences