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HAMAP annotation rule: MF_00427
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General rule information

Accession MF_00427
Dates 16-JUL-2001 (Created)
9-JUN-2011 (Last updated, Version 31)
Data class Protein
Predictors HAMAP; MF_00427; [distribution of match scores in UniProtKB];[seed alignment for MF_00427]
Names NqrC


Propagated annotation

Identifier, protein and gene names
Identifier NQRC
Protein name
RecName: Full=Na(+)-translocating NADH-quinone reductase subunit C;
Short=Na(+)-NQR subunit C;
Short=Na(+)-translocating NQR subunit C;
EC=1.6.5.-;
AltName: Full=NQR complex subunit C;
AltName: Full=NQR-1 subunit C;
Gene name nqrC
Comments
FUNCTION: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to nqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity).
CATALYTIC ACTIVITY: NADH + ubiquinone + Na(+)(In) = NAD(+) + ubiquinol + Na(+)(Out).
COFACTOR: FMN (By similarity).
SUBUNIT: Composed of six subunits; nqrA, nqrB, nqrC, nqrD, nqrE and nqrF (By similarity).

case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATION: Cell membrane (Potential).

else case <Property:Membrane=2>
SUBCELLULAR LOCATION: Cell inner membrane (Potential).
end case


case <FT:1>
CAUTION: The residue potentially involved in the covalent binding of FMN is a Ser instead of a Thr.
end case

SIMILARITY: Belongs to the nqrC family.
Cross-references
Pfam PF04205; FMN_bind; 1;
TIGRFAMs TIGR01938; NqrC; 1;
General Transmembrane; -; 1; trigger=Yes;
Keywords
Oxidoreductase, NAD, Ubiquinone, Transport, Ion transport, Sodium, Sodium transport, Flavoprotein, FMN, Membrane, Transmembrane, Cell membrane.

case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane.
end case


case <FT:1> or <FT:2>
Phosphoprotein.
end case

Transmembrane helix.
Gene Ontology
GO:0016655; Molecular function: oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor.
GO:0006814; Biological process: sodium ion transport.

case <Property:Membrane=2>
GO:0005886; Cellular component: plasma membrane.
end case

Features
From: NQRC_VIBAL (Q56582)
Key     From     To       Description   Condition   FTGroup
MOD_RES (Optional)     224     224       FMN phosphoryl serine (By similarity)   S  
MOD_RES (Optional)     224     224       FMN phosphoryl threonine (By similarity)   T  


Additional information

Size range: 244-320 amino acids
Related UniRules: None
Template: Q56582 (NQRC_VIBAL)
Scope: Bacteria
Fusion: Nter: None; Cter: None
Duplicate: None
Plasmid encoded: None

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UniProtKB rule member sequences