Home Proteomes Families Hamap-Scan Documents Downloads Links
HAMAP annotation rule: MF_00430
Send feedback new

General rule information

Accession MF_00430
Dates 19-JUL-2001 (Created)
7-OCT-2011 (Last updated, Version 35)
Data class Protein
Predictors HAMAP; MF_00430; [distribution of match scores in UniProtKB];[seed alignment for MF_00430]
Names NqrF


Propagated annotation

Identifier, protein and gene names
Identifier NQRF
Protein name
RecName: Full=Na(+)-translocating NADH-quinone reductase subunit F;
Short=Na(+)-NQR subunit F;
Short=Na(+)-translocating NQR subunit F;
EC=1.6.5.-;
AltName: Full=NQR complex subunit F;
AltName: Full=NQR-1 subunit F;
Gene name nqrF
Comments
FUNCTION: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by nqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity).
CATALYTIC ACTIVITY: NADH + ubiquinone + Na(+)(In) = NAD(+) + ubiquinol + Na(+)(Out).
COFACTOR: Binds 1 2Fe-2S cluster (By similarity).
COFACTOR: FAD (By similarity).
SUBUNIT: Composed of six subunits; nqrA, nqrB, nqrC, nqrD, nqrE and nqrF (By similarity).

case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATION: Cell membrane (Potential).

else case <Property:Membrane=2>
SUBCELLULAR LOCATION: Cell inner membrane (Potential).
end case

SIMILARITY: Belongs to the nqrF family.

case <Feature:PS51085>
SIMILARITY: Contains 1 2Fe-2S ferredoxin-type domain.
end case

Cross-references
Pfam PF00970; FAD_binding_6; 1;
PF00111; Fer2; 1;
PF00175; NAD_binding_1; 1;
PRINTS PR00371; FPNCR; 1;
TIGRFAMs TIGR01941; NqrF; 1;
PROSITE PS00197; 2FE2S_FER_1; 1;
PS51085; 2FE2S_FER_2; 1; trigger=PRU00465;
PS51384; FAD_FR; 1; trigger=PRU00716;
General Transmembrane; -; 1; trigger=Yes;
Keywords
Oxidoreductase, NAD, Ubiquinone, Transport, Ion transport, Sodium, Sodium transport, Flavoprotein, FAD.

case <Feature:PS51085>
Metal-binding, Iron-sulfur, Iron, 2Fe-2S.
end case

Membrane, Transmembrane.

case defined <Property:Membrane> and <Property:Membrane=2>
Cell membrane, Cell inner membrane.
end case

Transmembrane helix.
Gene Ontology
GO:0009055; Molecular function: electron carrier activity.
GO:0006814; Biological process: sodium ion transport.
GO:0055114; Biological process: oxidation-reduction process.
GO:0005886; Cellular component: plasma membrane.
Features
From: NQRF_VIBAL (Q56584)
Key     From     To       Description   Condition   FTGroup
METAL     69     69       Iron-sulfur (2Fe-2S) (By similarity)   C  
METAL     75     75       Iron-sulfur (2Fe-2S) (By similarity)   C  
METAL     78     78       Iron-sulfur (2Fe-2S) (By similarity)   C  
METAL     110     110       Iron-sulfur (2Fe-2S) (By similarity)   C  


Additional information

Size range: 405-431 amino acids
Related UniRules: None
Template: Q56584 (NQRF_VIBAL)
Scope: Bacteria
Fusion: Nter: None; Cter: None
Duplicate: None
Plasmid encoded: None

View rule in raw text format (no links)



UniProtKB rule member sequences