HAMAP

Accession	MF_00435
Dates	12-JUL-2001 (Created) 18-DEC-2012 (Last updated, Version 28)

Name

IlvC

Scope

Bacteria Archaea

Triggered by

HAMAP; MF_00435 (Get profile general information and statistics)

Identifier

ILVC

Protein name

RecName: Full=Ketol-acid reductoisomerase; EC=1.1.1.86; AltName: Full=Acetohydroxy-acid isomeroreductase; AltName: Full=Alpha-keto-beta-hydroxylacyl reductoisomerase;

Gene name

ilvC

CATALYTIC ACTIVITY	(R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH.
	(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH.
PATHWAY	Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate; step 2/4.
	Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate; step 2/4.
SIMILARITY	Belongs to the ketol-acid reductoisomerase family.

Oxidoreductase
Amino-acid biosynthesis
Branched-chain amino acid biosynthesis
NADP

GO:0004455; Molecular function: ketol-acid reductoisomerase activity.
GO:0009097; Biological process: isoleucine biosynthetic process.
GO:0009099; Biological process: valine biosynthetic process.

Pfam	PF01450; IlvC; 1;
TIGRFAMs	TIGR00465; IlvC; 1;

From: ILVC_ECOLI (P05793)

Key

From

To

Description

Tag

Condition

FTGroup

ACT_SITE

132

132

Potential

H

Size range:	326-494 amino acids
Related Rules:	None
Template:	Q57179 (ILVC_CORGL)
Fusion:	None
Comments:	Two additional divergent sequences in SULSO (SSO1322 and SSO1942) not shown in alignment. Enterobacteria have a large insert not found in other sequences.

View rule in raw text format (no links)