HAMAP

Accession	MF_00446
Dates	1-JUN-2001 (Created) 7-OCT-2011 (Last updated, Version 31)

Data class

Protein

Predictors

HAMAP; MF_00446; [distribution of match scores in UniProtKB];[seed alignment for MF_00446]

Names

PanD

Identifier

PAND

Protein name

RecName: Full=Aspartate 1-decarboxylase; EC=4.1.1.11; AltName: Full=Aspartate alpha-decarboxylase; RecName: Full=Aspartate 1-decarboxylase beta chain; RecName: Full=Aspartate 1-decarboxylase alpha chain; Flags: Precursor;

Gene name

panD

FUNCTION: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity).

CATALYTIC ACTIVITY: L-aspartate = beta-alanine + CO(2).

COFACTOR: Pyruvoyl group (By similarity).

PATHWAY: Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate: step 1/1.

SUBUNIT: Heterooctamer of four alpha and four beta subunits (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

PTM: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus (By similarity).

SIMILARITY: Belongs to the PanD family.

Pfam	PF02261; Asp_decarbox; 1;
TIGRFAMs	TIGR00223; PanD; 1;

Autocatalytic cleavage, Cytoplasm, Decarboxylase, Lyase, Pantothenate biosynthesis, Pyruvate, Schiff base, Zymogen.

GO:0004068; Molecular function: aspartate 1-decarboxylase activity.
GO:0015940; Biological process: pantothenate biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

From: PAND_ECOLI (P0A790)
Key		From		To		Description		Condition		FTGroup
CHAIN		Nter		24		Aspartate 1-decarboxylase beta chain (By similarity)
CHAIN		25		Cter		Aspartate 1-decarboxylase alpha chain (By similarity)
REGION		73		75		Substrate binding (By similarity)		G-[AGPS]-[AT]
ACT_SITE		25		25		Schiff-base intermediate with substrate; via pyruvic acid (By similarity)		S
ACT_SITE		58		58		Proton donor (By similarity)		Y
BINDING		57		57		Substrate (By similarity)		T
MOD_RES		25		25		Pyruvic acid (Ser) (By similarity)		S

Size range:	111-180 amino acids
Related UniRules:	None
Template:	P0A790 (PAND_ECOLI); P56065 (PAND_HELPY): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in ARTAT, FRASC, GLOVI, POLSJ, RHILO
Plasmid encoded:	in ARTAT, RHILO