HAMAP rule MF_00451
General rule information
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| Accession | MF_00451 |
| Dates | 18-SEP-2001 (Created)
28-JUN-2024 (Last updated, Version 45) |
| Name | NDP_kinase |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P0A763 (NDK_ECOLI); Q59636 (NDK_PSEAE); O85501 (NDK_MYCS2); P61136 (NDK_HALSA); [ Recover all ] |
| Triggered by |
HAMAP; MF_00451 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | NDK |
| Protein name | RecName: Full=Nucleoside diphosphate kinase; Short=NDK; Short=NDP kinase; EC=2.7.4.6; AltName: Full=Nucleoside-2-P kinase; |
| Gene name | Name=ndk; |
Comments
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| FUNCTION | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. |
| CATALYTIC ACTIVITY | Reaction=a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'- deoxyribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:44640, ChEBI:CHEBI:30616, ChEBI:CHEBI:61560, ChEBI:CHEBI:73316, ChEBI:CHEBI:456216; EC=2.7.4.6; |
| CATALYTIC ACTIVITY | Reaction=a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'- triphosphate + ADP; Xref=Rhea:RHEA:18113, ChEBI:CHEBI:30616, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557, ChEBI:CHEBI:456216; EC=2.7.4.6; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| case <OC:Bacteria> | |
| SUBUNIT | Homotetramer. |
| end case | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the NDK family. |
Keywords
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| Cytoplasm | |
| Magnesium | |
| Metal-binding | |
| Nucleotide metabolism | |
| Nucleotide-binding | |
| Phosphoprotein | |
| Transferase | |
| Kinase | |
| ATP-binding | |
| case <FT:8> or <FT:9> | |
| Phosphoprotein | |
| end case | |
Gene Ontology
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| GO:0005524; Molecular function:ATP binding |
| GO:0004550; Molecular function:nucleoside diphosphate kinase activity |
| GO:0006241; Biological process:CTP biosynthetic process |
| GO:0006183; Biological process:GTP biosynthetic process |
| GO:0006228; Biological process:UTP biosynthetic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF00334; NDK; 1; |
| PRINTS | PR01243; NUCDPKINASE; 1; |
| PROSITE | PS00469; NDPK; 1; |
| PROSITE | PS51374; NDPK_LIKE; 1; |
Features
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| From: NDK_ECOLI (P0A763) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 117 | 117 | /note="Pros-phosphohistidine intermediate" | H | ||||||||
| BINDING | 11 | 11 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
K | ||||||||
| BINDING | 59 | 59 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[FY] | ||||||||
| BINDING | 87 | 87 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
R | ||||||||
| BINDING | 93 | 93 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
T | ||||||||
| BINDING | 104 | 104 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
R | ||||||||
| BINDING | 114 | 114 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
N | ||||||||
| From: NDK_BACSU (P31103) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Bacillaceae> | ||||||||||||
| MOD_RES | 92 | 92 | /note="Phosphothreonine" | T | ||||||||
| MOD_RES | 123 | 123 | /note="Phosphoserine" | S | ||||||||
| end case | ||||||||||||
Additional information
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| Size range | 133-174 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | BORBU and PYRAE are divergent; not shown in alignment |