 |
|
| HAMAP annotation rule: MF_00451 |
| Accession |
MF_00451 |
| Dates |
18-SEP-2001 (Created) 13-DEC-2011 (Last updated, Version 35) |
| Protein name |
| RecName: |
Full=Nucleoside diphosphate kinase; Short=NDK; Short=NDP kinase; EC=2.7.4.6; |
| AltName: |
Full=Nucleoside-2-P kinase; |
|
FUNCTION: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).
CATALYTIC ACTIVITY: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
COFACTOR: Magnesium (By similarity).
case <OC:Bacteria>
SUBUNIT: Homotetramer (By similarity).
end case
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the NDK family.
case <FT:8> or <FT:9>
end case
GO:0005524; Molecular function: ATP binding.
GO:0004550; Molecular function: nucleoside diphosphate kinase activity.
GO:0006241; Biological process: CTP biosynthetic process.
GO:0006183; Biological process: GTP biosynthetic process.
GO:0006228; Biological process: UTP biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
| From: NDK_ECOLI (P0A763) |
| Key |
|
From |
|
To |
|
Description |
|
Condition |
|
FTGroup |
| ACT_SITE |
|
117 |
|
117 |
|
Pros-phosphohistidine intermediate (By similarity) |
|
H |
|
|
| BINDING |
|
11 |
|
11 |
|
ATP (By similarity) |
|
K |
|
|
| BINDING |
|
59 |
|
59 |
|
ATP (By similarity) |
|
[FY] |
|
|
| BINDING |
|
87 |
|
87 |
|
ATP (By similarity) |
|
R |
|
|
| BINDING |
|
93 |
|
93 |
|
ATP (By similarity) |
|
T |
|
|
| BINDING |
|
104 |
|
104 |
|
ATP (By similarity) |
|
R |
|
|
| BINDING |
|
114 |
|
114 |
|
ATP (By similarity) |
|
N |
|
|
case <OC:Bacillaceae>
| From: NDK_BACSU (P31103) |
| Key |
|
From |
|
To |
|
Description |
|
Condition |
|
FTGroup |
| MOD_RES |
|
92 |
|
92 |
|
Phosphothreonine (By similarity) |
|
T |
|
|
| MOD_RES |
|
123 |
|
123 |
|
Phosphoserine (By similarity) |
|
S |
|
|
end case
| Size range: |
133-174 amino acids |
| Related UniRules: |
None |
| Template: |
P0A763 (NDK_ECOLI) |
| Scope: |
Bacteria
Archaea |
| Fusion: |
Nter: None; Cter: None |
| Duplicate: |
in PARUW |
| Plasmid encoded: |
None |
| Comments: |
BORBU and PYRAE are divergent; not shown in alignment |
View rule in raw text format (no links)