HAMAP

Accession	MF_00451
Dates	18-SEP-2001 (Created) 13-DEC-2011 (Last updated, Version 35)

Data class

Protein

Predictors

HAMAP; MF_00451; [distribution of match scores in UniProtKB];[seed alignment for MF_00451]

Names

NDP_kinase

Identifier

NDK

Protein name

RecName: Full=Nucleoside diphosphate kinase; Short=NDK; Short=NDP kinase; EC=2.7.4.6; AltName: Full=Nucleoside-2-P kinase;

Gene name

ndk

FUNCTION: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).

CATALYTIC ACTIVITY: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.

COFACTOR: Magnesium (By similarity).

SUBUNIT: Homotetramer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the NDK family.

Pfam	PF00334; NDK; 1;
PRINTS	PR01243; NUCDPKINASE; 1;
PROSITE	PS00469; NDP_KINASES; 1;

Cytoplasm, Magnesium, Metal-binding, Nucleotide metabolism, Nucleotide-binding, Phosphoprotein, Transferase, Kinase, ATP-binding, Nucleotide-binding.

Phosphoprotein.

GO:0005524; Molecular function: ATP binding.
GO:0004550; Molecular function: nucleoside diphosphate kinase activity.
GO:0006241; Biological process: CTP biosynthetic process.
GO:0006183; Biological process: GTP biosynthetic process.
GO:0006228; Biological process: UTP biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

From: NDK_ECOLI (P0A763)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		117		117		Pros-phosphohistidine intermediate (By similarity)		H
BINDING		11		11		ATP (By similarity)		K
BINDING		59		59		ATP (By similarity)		[FY]
BINDING		87		87		ATP (By similarity)		R
BINDING		93		93		ATP (By similarity)		T
BINDING		104		104		ATP (By similarity)		R
BINDING		114		114		ATP (By similarity)		N

From: NDK_BACSU (P31103)
Key		From		To		Description		Condition		FTGroup
MOD_RES		92		92		Phosphothreonine (By similarity)		T
MOD_RES		123		123		Phosphoserine (By similarity)		S

Size range:	133-174 amino acids
Related UniRules:	None
Template:	P0A763 (NDK_ECOLI)
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in PARUW
Plasmid encoded:	None
Comments:	BORBU and PYRAE are divergent; not shown in alignment