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HAMAP rule MF_00451

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General rule information [?]

Accession MF_00451
Dates 18-SEP-2001 (Created)
19-NOV-2022 (Last updated, Version 43)
Name NDP_kinase
Scope(s) Bacteria
Archaea
Template(s) P0A763 (NDK_ECOLI); Q59636 (NDK_PSEAE); O85501 (NDK_MYCS2); P61136 (NDK_HALSA); [ Recover all ]
Triggered by HAMAP; MF_00451 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier NDK
Protein name RecName: Full=Nucleoside diphosphate kinase;
                 Short=NDK;
                 Short=NDP kinase;
                 EC=2.7.4.6;
AltName: Full=Nucleoside-2-P kinase;
Gene name Name=ndk;

Comments [?]

FUNCTIONMajor role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
CATALYTIC ACTIVITY Reaction=a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'- deoxyribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:44640, ChEBI:CHEBI:30616, ChEBI:CHEBI:61560, ChEBI:CHEBI:73316, ChEBI:CHEBI:456216; EC=2.7.4.6;
CATALYTIC ACTIVITY Reaction=a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'- triphosphate + ADP; Xref=Rhea:RHEA:18113, ChEBI:CHEBI:30616, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557, ChEBI:CHEBI:456216; EC=2.7.4.6;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
case <OC:Bacteria>
SUBUNITHomotetramer.
end case
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the NDK family.

Keywords [?]


Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0004550; Molecular function:nucleoside diphosphate kinase activity
GO:0006241; Biological process:CTP biosynthetic process
GO:0006183; Biological process:GTP biosynthetic process
GO:0006228; Biological process:UTP biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00334; NDK; 1;
PRINTS PR01243; NUCDPKINASE; 1;
PROSITE PS00469; NDP_KINASES; 1;

Features [?]

From: NDK_ECOLI (P0A763)
Key From To Description Tag Condition FTGroup
ACT_SITE 117 117 /note="Pros-phosphohistidine intermediate" H
BINDING 11 11 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
K
BINDING 59 59 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
[FY]
BINDING 87 87 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
R
BINDING 93 93 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
T
BINDING 104 104 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
R
BINDING 114 114 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
N
From: NDK_BACSU (P31103)
Key From To Description Tag Condition FTGroup
case <OC:Bacillaceae>
MOD_RES 92 92 /note="Phosphothreonine" T
MOD_RES 123 123 /note="Phosphoserine" S
end case

Additional information [?]

Size range 133-174 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments BORBU and PYRAE are divergent; not shown in alignment



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