HAMAP annotation rule MF_00451
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Accession MF_00451
Dates 18-SEP-2001 (Created)
13-DEC-2011 (Last updated, Version 35)
Name NDP_kinase
Scope Bacteria
Archaea
Triggered by



Identifier
NDK
Protein name
RecName: Full=Nucleoside diphosphate kinase;
Short=NDK;
Short=NDP kinase;
EC=2.7.4.6;
AltName: Full=Nucleoside-2-P kinase;
Gene name
ndk


FUNCTION Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).
CATALYTIC ACTIVITY ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
COFACTOR Magnesium (By similarity).
case <OC:Bacteria>
SUBUNIT Homotetramer (By similarity).
end case
SUBCELLULAR LOCATION Cytoplasm (By similarity).
SIMILARITY Belongs to the NDK family.


Cytoplasm
Magnesium
Metal-binding
Nucleotide metabolism
Nucleotide-binding
Phosphoprotein
Transferase
Kinase
ATP-binding
Nucleotide-binding
case <FT:8> or <FT:9>
Phosphoprotein
end case


GO:0005524; Molecular function: ATP binding.
GO:0004550; Molecular function: nucleoside diphosphate kinase activity.
GO:0006241; Biological process: CTP biosynthetic process.
GO:0006183; Biological process: GTP biosynthetic process.
GO:0006228; Biological process: UTP biosynthetic process.
GO:0005737; Cellular component: cytoplasm.


Pfam PF00334; NDK; 1;
PRINTS PR01243; NUCDPKINASE; 1;
PROSITE PS00469; NDP_KINASES; 1;


From: NDK_ECOLI (P0A763)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     117     117       Pros-phosphohistidine intermediate (By similarity)     H  
BINDING     11     11       ATP (By similarity)     K  
BINDING     59     59       ATP (By similarity)     [FY]  
BINDING     87     87       ATP (By similarity)     R  
BINDING     93     93       ATP (By similarity)     T  
BINDING     104     104       ATP (By similarity)     R  
BINDING     114     114       ATP (By similarity)     N  
case <OC:Bacillaceae>
From: NDK_BACSU (P31103)
MOD_RES     92     92       Phosphothreonine (By similarity)     T  
MOD_RES     123     123       Phosphoserine (By similarity)     S  
end case


Size range: 133-174 amino acids
Related Rules: None
Template: P0A763 (NDK_ECOLI)
Fusion: None
Comments: BORBU and PYRAE are divergent; not shown in alignment


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