HAMAP rule MF_00455
General rule information
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| Accession | MF_00455 |
| Dates | 24-SEP-2001 (Created)
1-JUN-2023 (Last updated, Version 43) |
| Name | Xylose_isom_A |
| Scope(s) |
Bacteria |
| Template(s) | P12851 (XYLA_ACTM4); P12070 (XYLA_ARTS7); P54272 (XYLA_BACSW); P00944 (XYLA_ECOLI); P15587 (XYLA_STROL); [ Recover all ] |
| Triggered by |
HAMAP; MF_00455 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | XYLA |
| Protein name | RecName: Full=Xylose isomerase; EC=5.3.1.5; |
| Gene name | Name=xylA; |
Comments
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| CATALYTIC ACTIVITY | Reaction=alpha-D-xylose = alpha-D-xylulofuranose; Xref=Rhea:RHEA:22816, ChEBI:CHEBI:28518, ChEBI:CHEBI:188998; EC=5.3.1.5; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 2 magnesium ions per subunit.; |
| SUBUNIT | Homotetramer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the xylose isomerase family. |
Keywords
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Gene Ontology
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| GO:0000287; Molecular function:magnesium ion binding |
| GO:0009045; Molecular function:xylose isomerase activity |
| GO:0042732; Biological process:D-xylose metabolic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF01261; AP_endonuc_2; 1; |
| PRINTS | PR00688; XYLOSISMRASE; 1; |
| NCBIfam | TIGR02630; Xylose_isom_A; 1; |
| PROSITE | PS51415; XYLOSE_ISOMERASE; 1; |
Features
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| From: XYLA_ACTM4 (P12851) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Actinomycetales> or <OC:Deinococci> | ||||||||||||
| ACT_SITE | 54 | 54 | H | |||||||||
| ACT_SITE | 57 | 57 | [DE] | |||||||||
| BINDING | 181 | 181 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1" |
E | ||||||||
| BINDING | 217 | 217 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1" |
E | ||||||||
| BINDING | 217 | 217 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2" |
E | ||||||||
| BINDING | 220 | 220 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2" |
H | ||||||||
| BINDING | 245 | 245 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1" |
D | ||||||||
| BINDING | 255 | 255 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2" |
D | ||||||||
| BINDING | 257 | 257 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2" |
D | ||||||||
| BINDING | 292 | 292 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1" |
D | ||||||||
| end case | ||||||||||||
| From: XYLA_ECOLI (P00944) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case not <OC:Actinomycetales> and not <OC:Deinococci> | ||||||||||||
| ACT_SITE | 101 | 101 | H | |||||||||
| ACT_SITE | 104 | 104 | [DE] | |||||||||
| BINDING | 232 | 232 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1" |
E | ||||||||
| BINDING | 268 | 268 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1" |
E | ||||||||
| BINDING | 268 | 268 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2" |
E | ||||||||
| BINDING | 271 | 271 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2" |
H | ||||||||
| BINDING | 296 | 296 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1" |
D | ||||||||
| BINDING | 307 | 307 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2" |
D | ||||||||
| BINDING | 309 | 309 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2" |
D | ||||||||
| BINDING | 339 | 339 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1" |
D | ||||||||
| end case | ||||||||||||
Additional information
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| Size range | 386-449 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |