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HAMAP rule MF_00455

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General rule information [?]

Accession MF_00455
Dates 24-SEP-2001 (Created)
1-JUN-2023 (Last updated, Version 43)
Name Xylose_isom_A
Scope(s) Bacteria
Template(s) P12851 (XYLA_ACTM4); P12070 (XYLA_ARTS7); P54272 (XYLA_BACSW); P00944 (XYLA_ECOLI); P15587 (XYLA_STROL); [ Recover all ]
Triggered by HAMAP; MF_00455 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier XYLA
Protein name RecName: Full=Xylose isomerase;
                 EC=5.3.1.5;
Gene name Name=xylA;

Comments [?]

CATALYTIC ACTIVITY Reaction=alpha-D-xylose = alpha-D-xylulofuranose; Xref=Rhea:RHEA:22816, ChEBI:CHEBI:28518, ChEBI:CHEBI:188998; EC=5.3.1.5;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 2 magnesium ions per subunit.;
SUBUNITHomotetramer.
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the xylose isomerase family.

Keywords [?]


Gene Ontology [?]

GO:0000287; Molecular function:magnesium ion binding
GO:0009045; Molecular function:xylose isomerase activity
GO:0042732; Biological process:D-xylose metabolic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF01261; AP_endonuc_2; 1;
PRINTS PR00688; XYLOSISMRASE; 1;
NCBIfam TIGR02630; Xylose_isom_A; 1;
PROSITE PS51415; XYLOSE_ISOMERASE; 1;

Features [?]

From: XYLA_ACTM4 (P12851)
Key From To Description Tag Condition FTGroup
case <OC:Actinomycetales> or <OC:Deinococci>
ACT_SITE 54 54 H
ACT_SITE 57 57 [DE]
BINDING 181 181 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="1"
E
BINDING 217 217 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="1"
E
BINDING 217 217 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="2"
E
BINDING 220 220 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="2"
H
BINDING 245 245 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="1"
D
BINDING 255 255 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="2"
D
BINDING 257 257 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="2"
D
BINDING 292 292 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="1"
D
end case
From: XYLA_ECOLI (P00944)
Key From To Description Tag Condition FTGroup
case not <OC:Actinomycetales> and not <OC:Deinococci>
ACT_SITE 101 101 H
ACT_SITE 104 104 [DE]
BINDING 232 232 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="1"
E
BINDING 268 268 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="1"
E
BINDING 268 268 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="2"
E
BINDING 271 271 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="2"
H
BINDING 296 296 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="1"
D
BINDING 307 307 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="2"
D
BINDING 309 309 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="2"
D
BINDING 339 339 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="1"
D
end case

Additional information [?]

Size range 386-449 amino acids
Related rules None
Fusion Nter: None Cter: None



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