HAMAP

Accession	MF_00456
Dates	26-SEP-2001 (Created) 7-OCT-2011 (Last updated, Version 31)

Data class

Protein

Predictors

HAMAP; MF_00456; [distribution of match scores in UniProtKB];[seed alignment for MF_00456]

Names

ProB

Identifier

PROB

Protein name

RecName: Full=Glutamate 5-kinase; EC=2.7.2.11; AltName: Full=Gamma-glutamyl kinase; Short=GK;

Gene name

proB

FUNCTION: Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5-oxoproline (By similarity).

CATALYTIC ACTIVITY: ATP + L-glutamate = ADP + L-glutamate 5-phosphate.

PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the glutamate 5-kinase family.

SIMILARITY: Contains 1 PUA domain.

Pfam	PF00696; AA_kinase; 1; PF01472; PUA; 1;
PIRSF	PIRSF000729; GK; 1;
PRINTS	PR00474; GLU5KINASE; 1;
TIGRFAMs	TIGR01027; ProB; 1;
PROSITE	PS00902; GLUTAMATE_5_KINASE; 1; PS50890; PUA; 0-1; trigger=PRU00161;

Amino-acid biosynthesis, ATP-binding, Cytoplasm, Kinase, Nucleotide-binding, Proline biosynthesis, Transferase.

GO:0004349; Molecular function: glutamate 5-kinase activity.
GO:0006561; Biological process: proline biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Size range:	251-397 amino acids
Related UniRules:	None
Template:	P0A7B5 (PROB_ECOLI); P17856 (PROB_SERMA); P96488 (PROB_STRTR): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in BACSU, PSEHT, RHILO, RHIME
Plasmid encoded:	None
Comments:	Possible wrong starts