HAMAP

Accession	MF_00470
Dates	24-OCT-2001 (Created) 13-DEC-2011 (Last updated, Version 24)

Data class

Protein

Predictors

HAMAP; MF_00470; [distribution of match scores in UniProtKB];[seed alignment for MF_00470]

Names

MenC_1

Identifier

MENC

Protein name

RecName: Full=o-succinylbenzoate synthase; Short=OSB synthase; Short=OSBS; EC=4.2.1.113; AltName: Full=4-(2'-carboxyphenyl)-4-oxybutyric acid synthase; AltName: Full=o-succinylbenzoic acid synthase;

Gene name

menC

FUNCTION: Converts SHCHC to OSB (By similarity).

CATALYTIC ACTIVITY: (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H(2)O.

COFACTOR: Divalent metal ions (By similarity).

PATHWAY: Cofactor biosynthesis; menaquinone biosynthesis; menaquinone-2 from chorismate: step 4/8.

SIMILARITY: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.

Pfam	PF01188; MR_MLE; 1;

Menaquinone biosynthesis, Lyase.

Magnesium, Metal-binding.

GO:0016836; Molecular function: hydro-lyase activity.
GO:0009234; Biological process: menaquinone biosynthetic process.

From: MENC_ECOLI (P29208)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		133		133		Proton donor (By similarity)		K
ACT_SITE		235		235		Proton acceptor (By similarity)		K
METAL		161		161		Magnesium (By similarity)		D		1
METAL		190		190		Magnesium (By similarity)		E		1
METAL		213		213		Magnesium (By similarity)		D		1

Size range:	320-337 amino acids
Related UniRules:	None
Template:	P29208 (MENC_ECOLI)
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None