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HAMAP rule MF_00473

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General rule information [?]

Accession MF_00473
Dates 25-OCT-2001 (Created)
11-NOV-2021 (Last updated, Version 44)
Name G6P_isomerase
Scope(s) Bacteria
Archaea
Template(s) P0A6T1 (G6PI_ECOLI); P0A0T1 (G6PI_XANCI); P28718 (G6PI_ZYMMO); Q9X1A5 (G6PI_THEMA); P9WN69 (G6PI_MYCTU); [ Recover all ]
Triggered by HAMAP; MF_00473 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier G6PI
case <OC:Bacteria>
Protein name RecName: Full=Glucose-6-phosphate isomerase;
                 Short=GPI;
                 EC=5.3.1.9;
AltName: Full=Phosphoglucose isomerase;
                 Short=PGI;
AltName: Full=Phosphohexose isomerase;
                 Short=PHI;
end case
case <OC:Archaea>
Protein name RecName: Full=Probable glucose-6-phosphate isomerase;
                 Short=GPI;
                 EC=5.3.1.9;
AltName: Full=Phosphoglucose isomerase;
                 Short=PGI;
AltName: Full=Phosphohexose isomerase;
                 Short=PHI;
end case
Gene name Name=pgi;

Comments [?]

FUNCTIONCatalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
CATALYTIC ACTIVITY Reaction=alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate; Xref=Rhea:RHEA:11816, ChEBI:CHEBI:57634, ChEBI:CHEBI:58225; EC=5.3.1.9;
PATHWAYCarbohydrate biosynthesis; gluconeogenesis.
PATHWAYCarbohydrate degradation; glycolysis; D-glyceraldehyde 3- phosphate and glycerone phosphate from D-glucose: step 2/4.
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the GPI family.

Keywords [?]

case <FT:4> or <FT:5> or <FT:6>
Acetylation
end case
Cytoplasm
Isomerase
Gluconeogenesis
Glycolysis
case <FT:7>
Phosphoprotein
end case

Gene Ontology [?]

GO:0004347; Molecular function:glucose-6-phosphate isomerase activity
GO:0006094; Biological process:gluconeogenesis
GO:0006096; Biological process:glycolytic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00342; PGI; 1;
PRINTS PR00662; G6PISOMERASE; 1;
PROSITE PS00765; P_GLUCOSE_ISOMERASE_1; 1;
PROSITE PS00174; P_GLUCOSE_ISOMERASE_2; 1;
PROSITE PS51463; P_GLUCOSE_ISOMERASE_3; 1;

Features [?]

From: G6PI_ECOLI (P0A6T1)
Key From To Description Tag Condition FTGroup
ACT_SITE 355 355 /note="Proton donor" E
ACT_SITE 386 386 H
ACT_SITE 514 514 K
case <OC:Escherichia> or <OC:Shigella>
MOD_RES 80 80 /note="N6-acetyllysine" K
MOD_RES 228 228 /note="N6-acetyllysine" K
MOD_RES 234 234 /note="N6-acetyllysine" K
end case
From: G6PI_BACSU (P80860)
Key From To Description Tag Condition FTGroup
case <OC:Bacillaceae>
MOD_RES 38 38 /note="Phosphothreonine" T
end case

Additional information [?]

Size range 401-562 amino acids
Related rules None
Fusion Nter: None Cter: None



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