HAMAP

Accession	MF_00476
Dates	26-OCT-2001 (Created) 7-OCT-2011 (Last updated, Version 24)

Data class

Protein

Predictors

HAMAP; MF_00476; [distribution of match scores in UniProtKB];[seed alignment for MF_00476]

Names

NikR

Identifier

NIKR

Protein name

RecName: Full=Putative nickel-responsive regulator;

Protein name

RecName: Full=Nickel-responsive regulator;

Gene name

nikR

FUNCTION: Transcriptional regulator (Potential).

FUNCTION: Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel (By similarity).

COFACTOR: Binds 1 nickel ion per subunit (By similarity).

SUBUNIT: Homotetramer (By similarity).

SIMILARITY: Belongs to the transcriptional regulatory CopG/NikR family.

Pfam	PF08753; NikR_C; 1; PF01402; RHH_1; 1;
TIGRFAMs	TIGR02793; NikR; 1;

Repressor.

Transcription, Transcription regulation, DNA-binding.

Nickel, Metal-binding.

GO:0016151; Molecular function: nickel ion binding.
GO:0003700; Molecular function: sequence-specific DNA binding transcription factor activity.
GO:0006355; Biological process: regulation of transcription, DNA-dependent.

From: NIKR_ECOLI (P0A6Z6)
Key		From		To		Description		Condition		FTGroup
METAL		76		76		Nickel (By similarity)		H		1
METAL		87		87		Nickel (By similarity)		H		1
METAL		89		89		Nickel (By similarity)		H		1
METAL		95		95		Nickel (By similarity)		C		1

Size range:	127-148 amino acids
Related UniRules:	None
Template:	P0A6Z6 (NIKR_ECOLI)
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in METAC, METMA, METTH
Plasmid encoded:	None