HAMAP rule MF_00486
General rule information
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| Accession | MF_00486 |
| Dates | 22-NOV-2001 (Created)
1-JUN-2023 (Last updated, Version 33) |
| Name | McH |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P94954 (MCH_METKA); O28344 (MCH_ARCFU); O85014 (MCH_METEA); [ Recover all ] |
| Triggered by |
HAMAP; MF_00486 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MCH |
| Protein name | RecName: Full=Methenyltetrahydromethanopterin cyclohydrolase; EC=3.5.4.27; AltName: Full=Methenyl-H4MPT cyclohydrolase; |
| Gene name | Name=mch; |
Comments
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| case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> | |
| FUNCTION | Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+). |
| else | |
| FUNCTION | Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl- H(4)MPT. |
| end case | |
| CATALYTIC ACTIVITY | Reaction=5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin; Xref=Rhea:RHEA:19053, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58018, ChEBI:CHEBI:58337; EC=3.5.4.27; |
| case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> | |
| PATHWAY | One-carbon metabolism; methanogenesis from CO(2); 5,10- methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 3/3. |
| end case | |
| case <OC:Archaeoglobales> | |
| PATHWAY | Metabolic intermediate metabolism; lactate oxidation. |
| end case | |
| case <OC:Bacteria> | |
| PATHWAY | One-carbon metabolism; formaldehyde degradation; formate from formaldehyde (H(4)MPT route): step 3/5. |
| end case | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the MCH family. |
Keywords
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| case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> | |
| Methanogenesis | |
| end case | |
| Cytoplasm | |
| One-carbon metabolism | |
| Hydrolase | |
Gene Ontology
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| GO:0018759; Molecular function:methenyltetrahydromethanopterin cyclohydrolase activity | |
| GO:0006730; Biological process:one-carbon metabolic process | |
| case <OCellular component:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> | |
| GO:0015948; Biological process:methanogenesis | |
| end case | |
| GO:0005737; Cellular component:cytoplasm | |
Cross-references
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Features
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Additional information
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| Size range | 311-337 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |