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HAMAP annotation rule: MF_00486
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General rule information

Accession MF_00486
Dates 22-NOV-2001 (Created)
22-JUN-2011 (Last updated, Version 28)
Data class Protein
Predictors HAMAP; MF_00486; [distribution of match scores in UniProtKB];[seed alignment for MF_00486]
Names McH


Propagated annotation

Identifier, protein and gene names
Identifier MCH
Protein name
RecName: Full=Methenyltetrahydromethanopterin cyclohydrolase;
EC=3.5.4.27;
AltName: Full=Methenyl-H4MPT cyclohydrolase;
Gene name mch
Comments

case <Property:METHANOG>
FUNCTION: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+) (By similarity).
end case


case not <Property:METHANOG>
FUNCTION: Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl-H(4)MPT (By similarity).
end case

CATALYTIC ACTIVITY: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H(2)O = 5-formyl-5,6,7,8-tetrahydromethanopterin.

case <Property:METHANOG>
PATHWAY: One-carbon metabolism; methanogenesis from CO(2); 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 3/3.
end case


case <OC:Archaeoglobales>
PATHWAY: Metabolic intermediate metabolism; lactate oxidation.
end case


case <OC:Bacteria>
PATHWAY: One-carbon metabolism; formaldehyde degradation; formate from formaldehyde (H(4)MPT route): step 3/5.
end case

SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the MCH family.
Cross-references
Pfam PF02289; MCH; 1;
TIGRFAMs TIGR03120; One_C_mch; 1;
Keywords

case <Property:METHANOG>
Methanogenesis.
end case

Cytoplasm, One-carbon metabolism, Hydrolase.
Gene Ontology
GO:0018759; Molecular function: methenyltetrahydromethanopterin cyclohydrolase activity.
GO:0006730; Biological process: one-carbon metabolic process.

case <Property:METHANOG>
GO:0015948; Biological process: methanogenesis.
end case

GO:0005737; Cellular component: cytoplasm.


Additional information

Size range: 311-337 amino acids
Related UniRules: None
Template: P94954 (MCH_METKA); O28344 (MCH_ARCFU); O85014 (MCH_METEA): [Recover all]
Scope: Bacteria
Archaea
Fusion: Nter: None; Cter: None
Duplicate: None
Plasmid encoded: None

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UniProtKB rule member sequences