HAMAP annotation rule MF_00487
Send feedback


Accession MF_00487
Dates 22-NOV-2001 (Created)
13-DEC-2011 (Last updated, Version 28)
Name Malate_dehydrog_3
Scope Bacteria
Archaea
Triggered by



Identifier
MDH
Protein name
RecName: Full=Malate dehydrogenase;
EC=1.1.1.37;
Gene name
mdh


FUNCTION Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity).
CATALYTIC ACTIVITY (S)-malate + NAD(+) = oxaloacetate + NADH.
SIMILARITY Belongs to the LDH/MDH superfamily. MDH type 3 family.


NAD
Oxidoreductase
Tricarboxylic acid cycle
case <FT:10>
Phosphoprotein
end case


GO:0030060; Molecular function: L-malate dehydrogenase activity.
GO:0006099; Biological process: tricarboxylic acid cycle.


Pfam PF02866; Ldh_1_C; 1;
PF00056; Ldh_1_N; 1;
PRINTS PR00086; LLDHDRGNASE; 1;
TIGRFAMs TIGR01771; L-LDH-NAD; 1;
TIGR01763; MalateDH_bact; 1;


From: MDH_HALMA (Q07841)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     8     14       NAD (By similarity)     G-x(1,2)-G-x-x-G  
NP_BIND     119     121       NAD (By similarity)     [VILT]-[GSNAT]-N  
ACT_SITE     176     176       Proton acceptor (By similarity)     H  
BINDING (Optional)     34     34       NAD (By similarity)     D  
BINDING     83     83       Substrate (By similarity)     R  
BINDING     89     89       Substrate (By similarity)     R  
BINDING     96     96       NAD (By similarity)     N  
BINDING     121     121       Substrate (By similarity)     N  
BINDING     152     152       Substrate (By similarity)     R  
case <OC:Bacillaceae>
From: MDH_BACSU (P49814)
MOD_RES     149     149       Phosphoserine (By similarity)     S  
end case


Size range: 278-335 amino acids
Related Rules: MF_00488 (LDH (supersedes the current rule)); MF_01516 (MDH); MF_01517 (MDH)
Templates: P80040 (MDH_CHLAA); P80039 (MDH_CHLTE); O08349 (MDH_ARCFU); Q07841 (MDH_HALMA); Q60176 (MDH_METJA); P61889 (MDH_ECOLI): [Recover all]
Fusion: None
Comments: Also called LDH-like MDH


View rule in raw text format (no links)