HAMAP

Accession	MF_00488
Dates	23-NOV-2001 (Created) 10-MAY-2011 (Last updated, Version 37)

Data class

Protein

Predictors

HAMAP; MF_00488; [distribution of match scores in UniProtKB];[seed alignment for MF_00488]

Names

Lactate_dehydrog

Identifier

LDH

Protein name

RecName: Full=L-lactate dehydrogenase; Short=L-LDH; EC=1.1.1.27;

Gene name

ldh

CATALYTIC ACTIVITY: (S)-lactate + NAD(+) = pyruvate + NADH.

PATHWAY: Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.

SUBUNIT: Homotetramer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the LDH/MDH superfamily. LDH family.

Pfam	PF02866; Ldh_1_C; 1; PF00056; Ldh_1_N; 1;
PRINTS	PR00086; LLDHDRGNASE; 1;
TIGRFAMs	TIGR01771; L-LDH-NAD; 1; TIGR01763; MalateDH_bact; 1;
PROSITE	PS00064; L_LDH; 1;

Cytoplasm, Oxidoreductase, NAD, Glycolysis.

Phosphoprotein.

Stress response.

GO:0004459; Molecular function: L-lactate dehydrogenase activity.
GO:0006096; Biological process: glycolysis.
GO:0005737; Cellular component: cytoplasm.

From: LDH_GEOSE (P00344)
Key		From		To		Description		Condition		FTGroup
NP_BIND		15		43		NAD (By similarity)
ACT_SITE		179		179		Proton acceptor (By similarity)		H
BINDING		92		92		Substrate (By similarity)		R
BINDING		124		124		NAD or substrate (By similarity)		N
BINDING		155		155		Substrate (By similarity)		R
BINDING		233		233		Substrate (By similarity)		T
From: LDH_BACSU (P13714)
MOD_RES (Optional)		223		223		Phosphotyrosine (By similarity)		Y

Size range:	304-330 amino acids
Related UniRules:	MF_00487 (MDH); MF_01516 (MDH); MF_01517 (MDH)
Template:	P0CW93 (LDH2_BIFLO); P00344 (LDH_GEOSE); P00343 (LDH_LACCA); O32765 (LDH_LACHE); P16115 (LDH_THEMA): [Recover all]
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	in BACAN, BACC1, BACCR, BACCZ, BACHK, BIFLO, CLOAB, ENTFA, LACAC, LACJO, LACLA, LACLC, LACPL, LISIN, LISMO, STAA1, STAA2, STAA3, STAA8, STAA9, STAAB, STAAC, STAAE, STAAM, STAAN, STAAR, STAAS, STAAT, STAAW
Plasmid encoded:	None