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Annotation rule MF_00491
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General rule information [?]

Accession MF_00491
Dates 31-OCT-2001 (Created)
26-SEP-2014 (Last updated, Version 33)
Name NDH1_NuoM
Scope Bacteria; Cyanobacteria
Template P72823 (NU4C2_SYNY3)

Propagated annotation [?]

Identifier, protein and gene names [?]

case not <OG:Chloroplast>
Protein name
RecName: Full=NAD(P)H-quinone oxidoreductase chain 4;
AltName: Full=NAD(P)H dehydrogenase I, chain 4;
AltName: Full=NDH-1, chain 4;
end case
case <OG:Chloroplast>
Protein name
RecName: Full=NAD(P)H-quinone oxidoreductase chain 4, chloroplastic;
AltName: Full=NAD(P)H dehydrogenase, chain 4;
AltName: Full=NADH-plastoquinone oxidoreductase chain 4;
end case
Gene name

Comments [?]

case not <OG:Chloroplast>
Function NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
end case
Catalytic activity NAD(P)H + plastoquinone = NAD(P)(+) + plastoquinol.
case <OG:Chloroplast>
Subcellular location Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
else case <OC:Gloeobacter>
Subcellular location Cell inner membrane; Multi-pass membrane protein.
Subcellular location Cellular thylakoid membrane; Multi-pass membrane protein.
end case
Similarity Belongs to the complex I subunit 4 family.

Keywords [?]

case <OC:Gloeobacter>
end case

Gene Ontology [?]

GO:0016655; Molecular function: oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor.
GO:0055114; Biological process: oxidation-reduction process.
case <OG:Chloroplast>
GO:0009535; Cellular component: chloroplast thylakoid membrane.
else case <OC:Gloeobacter>
GO:0005886; Cellular component: plasma membrane.
GO:0042651; Cellular component: thylakoid membrane.
end case

Cross-references [?]

Pfam PF00361; Oxidored_q1; 1;

Computed features [?]

General Transmembrane; -; 12-15; trigger=yes;

Additional information [?]

Size range 493-563 amino acids
Related rules None
Fusion None
Comments In dicots the initiation codon seems to be created by RNA editing (has been proven for TOBAC, ARATH, SPIOL, OENEH and snapdragon).