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HAMAP annotation rule: MF_00495
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General rule information

Accession MF_00495
Dates 29-NOV-2001 (Created)
22-DEC-2010 (Last updated, Version 27)
Data class Protein
Predictors HAMAP; MF_00495; [distribution of match scores in UniProtKB];[seed alignment for MF_00495]
Names GPH_hydrolase_bact


Propagated annotation

Identifier, protein and gene names
Identifier GPH
Protein name
RecName: Full=Phosphoglycolate phosphatase;
Short=PGP;
Short=PGPase;
EC=3.1.3.18;

case not <Property:PHOTOSYN> and not <Property:CHEMOAUTOTROPHY>
Gene name gph
end case


case <Property:PHOTOSYN> or <Property:CHEMOAUTOTROPHY>
Gene name cbbZ
end case

Comments

case <OC:Proteobacteria>
FUNCTION: Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity).
end case


case not <OC:Proteobacteria>
FUNCTION: Specifically catalyzes the dephosphorylation of 2-phosphoglycolate (By similarity).
end case

CATALYTIC ACTIVITY: 2-phosphoglycolate + H(2)O = glycolate + phosphate.

case <OC:Enterobacteriaceae>
COFACTOR: Chloride (By similarity).
COFACTOR: Magnesium (By similarity).
SUBUNIT: Monomer (By similarity).
end case

PATHWAY: Organic acid metabolism; glycolate biosynthesis; glycolate from 2-phosphoglycolate: step 1/1.
SIMILARITY: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
Cross-references
Pfam PF00702; Hydrolase; 1;
PRINTS PR00413; HADHALOGNASE; 1;
Keywords
Carbohydrate metabolism.

case <Property:PHOTOSYN> or <Property:CHEMOAUTOTROPHY>
Calvin cycle.
end case


case <Property:PHOTOSYN>
Photosynthesis.
end case

Hydrolase.

case <OC:Enterobacteriaceae>
Chloride, Magnesium.
end case

Gene Ontology
GO:0008967; Molecular function: phosphoglycolate phosphatase activity.
GO:0005975; Biological process: carbohydrate metabolic process.

case <Property:PHOTOSYN> or <Property:CHEMOAUTOTROPHY>
GO:0019253; Biological process: reductive pentose-phosphate cycle.
end case

Features
From: GPH_ECOLI (P32662)
Key     From     To       Description   Condition   FTGroup
ACT_SITE     13     13       Nucleophile (By similarity)   D  


Additional information

Size range: 212-272 amino acids
Related UniRules: None
Template: P32662 (GPH_ECOLI); P40852 (GPHC_CUPNH); P40853 (GPHP_CUPNH): [Recover all]
Scope: Bacteria
Fusion: Nter: None; Cter: None
Duplicate: in CUPNH, PSEAE
Plasmid encoded: in CUPNH
Comments: Possible overlap with other paralogous genes in many genomes. Divergent gph in SYNE7 not shown in alignment as it could well be a paralog.

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UniProtKB rule member sequences