HAMAP rule MF_00504
General rule information
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| Accession | MF_00504 |
| Dates | 3-DEC-2001 (Created)
19-NOV-2022 (Last updated, Version 31) |
| Name | Aminopeptidase_M17 |
| Scope(s) |
Bacteria |
| Template(s) | P37095 (PEPB_ECOLI); Q9RF52 (PEPB_SALTY); [ Recover all ] |
| Triggered by |
HAMAP; MF_00504 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PEPB |
| Protein name | RecName: Full=Peptidase B; EC=3.4.11.23; AltName: Full=Aminopeptidase B; |
| Gene name | Name=pepB; |
Comments
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| FUNCTION | Probably plays an important role in intracellular peptide degradation. |
| CATALYTIC ACTIVITY | Reaction=Release of an N-terminal amino acid, Xaa, from a peptide or arylamide. Xaa is preferably Glu or Asp but may be other amino acids, including Leu, Met, His, Cys and Gln.; EC=3.4.11.23; |
| COFACTOR | Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 manganese ions per subunit.; |
| SUBUNIT | Homohexamer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the peptidase M17 family. |
Keywords
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Gene Ontology
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| GO:0004177; Molecular function:aminopeptidase activity |
| GO:0030145; Molecular function:manganese ion binding |
| GO:0006508; Biological process:proteolysis |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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| From: PEPB_ECOLI (P37095) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 207 | 207 | K | |||||||||
| ACT_SITE | 281 | 281 | R | |||||||||
| BINDING | 195 | 195 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2" |
K | ||||||||
| BINDING | 200 | 200 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1" |
D | ||||||||
| BINDING | 200 | 200 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2" |
D | ||||||||
| BINDING | 218 | 218 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2" |
D | ||||||||
| BINDING | 277 | 277 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1" |
D | ||||||||
| BINDING | 279 | 279 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1" |
E | ||||||||
| BINDING | 279 | 279 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2" |
E | ||||||||
Additional information
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| Size range | 427-456 amino acids |
| Related rules |
MF_00181 |
| Fusion | Nter: None Cter: None |