HAMAP

Accession	MF_00510
Dates	17-DEC-2001 (Created) 22-OCT-2010 (Last updated, Version 22)

Data class

Protein

Predictors

HAMAP; MF_00510; [distribution of match scores in UniProtKB];[seed alignment for MF_00510]

Names

Peptidase_E

Identifier

PEPE

Protein name

RecName: Full=Peptidase E; EC=3.4.13.21; AltName: Full=Alpha-aspartyl dipeptidase; AltName: Full=Asp-specific dipeptidase; AltName: Full=Dipeptidase E;

Gene name

pepE

FUNCTION: Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity).

CATALYTIC ACTIVITY: Dipeptidase E catalyzes the hydrolysis of dipeptides Asp-|-Xaa. It does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides.

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the peptidase S51 family.

Pfam	PF03575; Peptidase_S51; 1;

Cytoplasm, Hydrolase, Protease, Serine protease, Dipeptidase.

GO:0016805; Molecular function: dipeptidase activity.
GO:0006508; Biological process: proteolysis.
GO:0005737; Cellular component: cytoplasm.

From: PEPE_SALTY (P36936)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		120		120		Charge relay system (By similarity)		S
ACT_SITE		135		135		Charge relay system (By similarity)		D
ACT_SITE		157		157		Charge relay system (By similarity)		H

Size range:	218-243 amino acids
Related UniRules:	None
Template:	P36936 (PEPE_SALTY)
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	in NOSS1