Due to scheduled maintenance work, this service may not be available on Monday January 22nd between 08.00 am and 9.00 am CEST.
To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https
Annotation rule MF_00526
Send feedback

General rule information [?]

Accession MF_00526
Dates 16-JAN-2002 (Created)
10-OCT-2014 (Last updated, Version 26)
Name Me_Asp_mutase_S
Scope Bacteria
Templates P80078 (GMSS_CLOCO); Q05488 (GMSS_CLOTT): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Glutamate mutase sigma subunit;
AltName: Full=Glutamate mutase S chain;
AltName: Full=Glutamate mutase small subunit;
AltName: Full=Methylaspartate mutase;
Gene name

Comments [?]

Function Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).
Catalytic activity L-threo-3-methylaspartate = L-glutamate.
Cofactor adenosylcob(III)alamin
Pathway Amino-acid degradation; L-glutamate degradation via mesaconate pathway; acetate and pyruvate from L-glutamate: step 1/4.
Subunit Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer.
Similarity Belongs to the methylaspartate mutase GlmS subunit family.

Keywords [?]

Gene Ontology [?]

GO:0050097; Molecular function: methylaspartate mutase activity.
GO:0019670; Biological process: anaerobic glutamate catabolic process.

Cross-references [?]

Pfam PF02310; B12-binding; 1;
PROSITE PS51332; B12_BINDING; 1; trigger=PRU00666;
TIGRFAMs TIGR01501; MthylAspMutase; 1;

Features [?]

From: GMSS_CLOCO (P80078)
Key     From     To       Description   Tag   Condition   FTGroup
REGION (Optional)     13     17       Adenosylcobalamin binding     [SA]-D-[CVA]-H-[ATV]  
REGION (Optional)     61     63       Adenosylcobalamin binding     S-S-[LI]  
REGION (Optional)     93     97       Adenosylcobalamin binding     N-[LI]-[VGA]-[VI]-[G]  
METAL     16     16       Cobalt (cobalamin axial ligand)     H  

Additional information [?]

Size range 130-175 amino acids
Related rules None
Fusion None