HAMAP

Accession	MF_00540
Dates	27-FEB-2002 (Created) 10-OCT-2011 (Last updated, Version 16)

Data class

Protein

Predictors

HAMAP; MF_00540; [distribution of match scores in UniProtKB];[seed alignment for MF_00540]

Names

A_deaminase

Identifier

ADD

Protein name

RecName: Full=Adenosine deaminase; EC=3.5.4.4; AltName: Full=Adenosine aminohydrolase;

Gene name

add

CATALYTIC ACTIVITY: Adenosine + H(2)O = inosine + NH(3).

COFACTOR: Binds 1 zinc ion per subunit (By similarity).

SIMILARITY: Belongs to the adenosine and AMP deaminases family. Adenosine deaminase subfamily.

Pfam	PF00962; A_deaminase; 1;
TIGRFAMs	TIGR01430; Aden_deam; 1;
PROSITE	PS00485; A_DEAMINASE; 1;

Hydrolase, Nucleotide metabolism.

Metal-binding, Zinc.

GO:0004000; Molecular function: adenosine deaminase activity.
GO:0009168; Biological process: purine ribonucleoside monophosphate biosynthetic process.

GO:0008270; Molecular function: zinc ion binding.

From: ADD_ECOLI (P22333)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		200		200		Proton donor (By similarity)		E
METAL		12		12		Zinc; catalytic (By similarity)		H		1
METAL		14		14		Zinc; catalytic (By similarity)		H		1
METAL		197		197		Zinc; catalytic (By similarity)		H		1
METAL		278		278		Zinc; catalytic (By similarity)		D		1
BINDING (Optional)		14		14		Substrate (By similarity)		H
BINDING (Optional)		16		16		Substrate (By similarity)		D
BINDING (Optional)		170		170		Substrate; via amide nitrogen and carbonyl oxygen (By similarity)		G
BINDING (Optional)		279		279		Substrate (By similarity)		D
SITE		221		221		Important for catalytic activity (By similarity)		H

Size range:	299-396 amino acids
Related UniRules:	None
Template:	P22333 (ADD_ECOLI)
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	in STRCO
Plasmid encoded:	None
Comments:	Possible wrong start in STRCO.